Masashi Kudo1,2,3, Tatsushi Kobayashi4, Naoto Gotohda2, Masaru Konishi2, Shinichiro Takahashi2, Shin Kobayashi2, Motokazu Sugimoto2, Satoshi Okubo2, John Martin5, Horacio Cabral5, Genichiro Ishii1,3, Motohiro Kojima1. 1. From the Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center. 2. Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital East, Kashiwa. 3. Course of Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Tokyo. 4. Department of Diagnostic Radiology, National Cancer Center Hospital East, Kashiwa. 5. Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Abstract
OBJECTIVES: Tumor necrosis is often found in pancreatic ductal adenocarcinoma (PDAC). Objective histological assessment and adequate radiological detection of necrosis could be used as biomarkers for therapeutic decision. However, standardized clinical utility of necrosis remains unknown. Here, we aimed to determine the prognostic potential of histological and radiological evaluations of necrosis. METHODS: We investigated histological necrosis in 221 patients, who underwent surgery for PDAC, and classified its size as small (≤5 mm) or large (>5 mm). We also evaluated poorly enhanced areas on preoperative computed tomography to assess their ability for predicting histological necrosis and postoperative prognosis. RESULTS: Tumor necrosis was found in 115 patients (52%) and was related to tumor area, lymph node metastasis, and lymphovascular invasion. Size of necrosis was significantly associated with tumor area, perimeter of necrosis, circularity of necrosis, number of ruptured cancer glands, and presence of collagen bundle (P < 0.05 for all). Both presence of necrosis and their size were strongly correlated to postoperative prognosis. Patients with poorly enhanced areas showed worse prognosis (P < 0.01). CONCLUSIONS: Our findings underline the capacity of histological and radiological assessment of tumor necrosis for prognosis prediction in PDAC.
OBJECTIVES:Tumor necrosis is often found in pancreatic ductal adenocarcinoma (PDAC). Objective histological assessment and adequate radiological detection of necrosis could be used as biomarkers for therapeutic decision. However, standardized clinical utility of necrosis remains unknown. Here, we aimed to determine the prognostic potential of histological and radiological evaluations of necrosis. METHODS: We investigated histological necrosis in 221 patients, who underwent surgery for PDAC, and classified its size as small (≤5 mm) or large (>5 mm). We also evaluated poorly enhanced areas on preoperative computed tomography to assess their ability for predicting histological necrosis and postoperative prognosis. RESULTS:Tumor necrosis was found in 115 patients (52%) and was related to tumor area, lymph node metastasis, and lymphovascular invasion. Size of necrosis was significantly associated with tumor area, perimeter of necrosis, circularity of necrosis, number of ruptured cancer glands, and presence of collagen bundle (P < 0.05 for all). Both presence of necrosis and their size were strongly correlated to postoperative prognosis. Patients with poorly enhanced areas showed worse prognosis (P < 0.01). CONCLUSIONS: Our findings underline the capacity of histological and radiological assessment of tumor necrosis for prognosis prediction in PDAC.