Electrochemical strategy with zeolitic imidazolate framework-8 and ordered mesoporous carbon for detection of xanthine.

An accurate, safe, environmentally friendly, fast and sensitive electrochemical biosensors were developed to detect xanthine in serum. The metal-organic framework ZIF-8 was synthesised and elemental gold was supported on the surface of ZIF-8 by reduction method to synthesise Ag-ZIF-8. The mesoporous carbon material and the synthesised Ag-ZIF-8 were, respectively, applied to a glassy carbon electrode to construct biosensors. The constructed biosensor has a good linear relation in the range of 1-280 μmol l-1 of xanthine and the detection limit is 0.167 μmol l-1. The relative standard deviation value in serum samples was <5%, and the recoveries were 96-106%, indicating the good selectivity, stability and reproducibility of this electrochemical biosensor.