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Literature DB >> 32432929

Cardiac tissue remodeling in healthy aging: the road to pathology.

Evan Tracy¹, Gabrielle Rowe¹, Amanda J LeBlanc¹.

Abstract

This review aims to highlight the normal physiological remodeling that occurs in healthy aging hearts, including changes that occur in contractility, conduction, valve function, large and small coronary vessels, and the extracellular matrix. These "normal" age-related changes serve as the foundation that supports decreased plasticity and limited ability for tissue remodeling during pathophysiological states such as myocardial ischemia and heart failure. This review will identify populations at greater risk for poor tissue remodeling in advanced age along with present and future therapeutic strategies that may ameliorate dysfunctional tissue remodeling in aging hearts.

Entities: Disease

Keywords: aging; cardiac; remodeling

Mesh：

Year: 2020 PMID： 32432929 PMCID： PMC7468888 DOI： 10.1152/ajpcell.00021.2020

Source DB: PubMed Journal: Am J Physiol Cell Physiol ISSN： 0363-6143 Impact factor: 4.249

194 in total

Cardiac tissue remodeling in healthy aging: the road to pathology.

1. Heart regeneration in zebrafish.

2. Proinflammatory profile within the grossly normal aged human aortic wall.

3. Left ventricular strain examination of different aged adults with 3D speckle tracking echocardiography.

Review 4. Cardiac regeneration strategies: Staying young at heart.

5. Human endothelial cell life extension by telomerase expression.

6. Declining into failure: the age-dependent loss of the L-type calcium channel within the sinoatrial node.

7. Mesenchymal stem cells restore CCl4-induced liver injury by an antioxidative process.

8. Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice.

Review 9. The immune system and cardiac repair.

10. G protein-coupled estrogen receptor (GPER) deficiency induces cardiac remodeling through oxidative stress.

Review 1. State of the field: cellular and exosomal therapeutic approaches in vascular regeneration.

2. We are the change we seek.

Review 3. CVD and COVID-19: Emerging Roles of Cardiac Fibroblasts and Myofibroblasts.