Saman Khan1, Sohaib Naim1, Rania Bilwani1, Amirah Salem1, David Gorlin1, Ahmad Muhammad1, Maryam Gul2, Muhammad H Imam3, Ammar Chaudhry4. 1. Department of Diagnostic Radiology, City of Hope National Cancer Center, 1500 East Duarte Road, Los Angeles, CA, 91010, USA. 2. Amaze Research Foundation, Los Angeles, CA, USA. 3. Florida Cancer Specialists, Orlando, FL, USA. 4. Department of Diagnostic Radiology, City of Hope National Cancer Center, 1500 East Duarte Road, Los Angeles, CA, 91010, USA. achaudhry@coh.org.
Abstract
PURPOSE OF REVIEW: Imaging features of lymphoma vary regionally. Awareness of site-specific key imaging characteristics of lymphoma can aid in rapid staging and assist in prompt treatment. FDG PET/CT and conventional MRI are readily available diagnostic modalities with excellent sensitivity and good specificity. Diagnostic specificity can be enhanced using emerging PET radiotracers, e.g., FLT and FET. RECENT FINDINGS: Emerging research has shown higher dimensional analysis (radiomics and radiogenomics) of imaging data can yield information of the underlying genetic aberrations in lymphoma, which can aid in assessing real-time evolution of tumor. CT, PET/CT, MRI, and ultrasound accentuate the intrinsic qualities of lymphoma (e.g., FDG PET/CT for increased metabolic activity, FLT PET/CT for increased proliferation index, and DWI for increased cellularity) and play an essential role in its diagnosis and examination. Advanced radiogenomic analyses use radiomic parameters to deduce genetic variations of lymphoma, providing noninvasive, repeatable, and real-time surveillance of its genetic progression.
PURPOSE OF REVIEW: Imaging features of lymphoma vary regionally. Awareness of site-specific key imaging characteristics of lymphoma can aid in rapid staging and assist in prompt treatment. FDG PET/CT and conventional MRI are readily available diagnostic modalities with excellent sensitivity and good specificity. Diagnostic specificity can be enhanced using emerging PET radiotracers, e.g., FLT and FET. RECENT FINDINGS: Emerging research has shown higher dimensional analysis (radiomics and radiogenomics) of imaging data can yield information of the underlying genetic aberrations in lymphoma, which can aid in assessing real-time evolution of tumor. CT, PET/CT, MRI, and ultrasound accentuate the intrinsic qualities of lymphoma (e.g., FDG PET/CT for increased metabolic activity, FLT PET/CT for increased proliferation index, and DWI for increased cellularity) and play an essential role in its diagnosis and examination. Advanced radiogenomic analyses use radiomic parameters to deduce genetic variations of lymphoma, providing noninvasive, repeatable, and real-time surveillance of its genetic progression.
Authors: Johanna S Enke; Jan H Moltz; Melvin D'Anastasi; Wolfgang G Kunz; Christian Schmidt; Stefan Maurus; Alexander Mühlberg; Alexander Katzmann; Michael Sühling; Horst Hahn; Dominik Nörenberg; Thomas Huber Journal: Cancers (Basel) Date: 2022-01-29 Impact factor: 6.639