Takashi Anayama1, Takayuki Sato2, Kentaro Hirohashi3, Ryohei Miyazaki3, Marino Yamamoto3, Hironobu Okada3, Kazumasa Orihashi4, Keiji Inoue5, Michiya Kobayashi6, Masashi Yoshida7, Kazuhiro Hanazaki5. 1. Department of Thoracic Surgery, Kochi Medical School, Kochi University, Kohasu Oko, Nankoku, 783-8505, Japan. anayamat@kochi-u.ac.jp. 2. Department of Cardiovascular Control, Kochi Medical School, Nankoku, Japan. 3. Department of Thoracic Surgery, Kochi Medical School, Kochi University, Kohasu Oko, Nankoku, 783-8505, Japan. 4. Department of Surgery II, Kochi Medical School, Nankoku, Japan. 5. Center for Photodynamic Medicine, Kochi Medical School, Kochi University, Nankoku, Japan. 6. Cancer Treatment Center, Kochi Medical School Hospital, Nankoku, Japan. 7. Department of Surgery, International University of Health and Welfare Hospital, Nasushiobara, Japan.
Abstract
BACKGROUND: In clinical practice, various devices are implanted into the body for medical reasons. As X-ray fluoroscopy is necessary to visualize medical devices implanted into the body, the development of a less-invasive visualization method is highly desired. This study aimed to investigate the clinical applicability of our novel solid material that emits near-infrared fluorescence. METHODS: We developed a solid resin material that emits near-infrared fluorescence. This material incorporates a near-infrared fluorescent pigment, with quantum yield ≥ 20 times than that of indocyanine green. It can be sterilized for medical treatment. This resin material is designed to be molded into a catheter and inserted into the body with an endoscope clip. In this preclinical experiment using a swine model, the resin material was embedded into the body of the swine and visualized with a near-infrared fluorescence camera system. RESULTS: Endoscopic clips were placed in the mucosa of the stomach, esophagus, and large intestine, and the indwelling ureteral catheters were successfully visualized by near-infrared fluorescence laparoscopy. CONCLUSIONS: We confirmed the tissue permeability of the fluorescence emitted by our novel near-infrared fluorescent material and the possibility of its clinical application. This material may allow visualization of devices embedded in the body.
BACKGROUND: In clinical practice, various devices are implanted into the body for medical reasons. As X-ray fluoroscopy is necessary to visualize medical devices implanted into the body, the development of a less-invasive visualization method is highly desired. This study aimed to investigate the clinical applicability of our novel solid material that emits near-infrared fluorescence. METHODS: We developed a solid resin material that emits near-infrared fluorescence. This material incorporates a near-infrared fluorescent pigment, with quantum yield ≥ 20 times than that of indocyanine green. It can be sterilized for medical treatment. This resin material is designed to be molded into a catheter and inserted into the body with an endoscope clip. In this preclinical experiment using a swine model, the resin material was embedded into the body of the swine and visualized with a near-infrared fluorescence camera system. RESULTS: Endoscopic clips were placed in the mucosa of the stomach, esophagus, and large intestine, and the indwelling ureteral catheters were successfully visualized by near-infrared fluorescence laparoscopy. CONCLUSIONS: We confirmed the tissue permeability of the fluorescence emitted by our novel near-infrared fluorescent material and the possibility of its clinical application. This material may allow visualization of devices embedded in the body.