Additional laboratory tests to improve on the diagnosis of antiphospholipid syndrome.

Whether additional tests to improve on the diagnosis of antiphospholipid syndrome are useful is a matter of debate. New tests exploring the presence of antiphospholipid antibodies are now available and comprise subgroups of antibodies directed to β2-glycoprotein I, namely anti-Domain 1 and anti-Domain 4/5, and anti-phosphatidylserine/prothrombin antibodies. The aim of this article is to discuss in a forum with the scientific community on the possible utility of additional test for the diagnosis of antiphospholipid syndrome, especially in incomplete antiphospholipid antibody profiles.