| Literature DB >> 32428568 |
Hamideh Aboutalebi1, Afsane Bahrami2, Atena Soleimani3, Nikoo Saeedi4, Farzad Rahmani5, Majid Khazaei6, Hamid Fiuji7, Mojtaba Shafiee8, Gordon A Ferns9, Amir Avan10, Seyed Mahdi Hassanian11.
Abstract
Ovarian cancer (OC) is often diagnosed at an advanced stage because of the late onset of symptoms, and this together with the lack of effective treatments, has meant it is associated with a very high mortality. The aberrant expression of MicroRNA (miRNA) contributes to the initiation and development of human tumors including OC. Several miRNAs are secreted by tumor cells and can be identified in body fluids. Serum miRNAs levels are associated with several clinical conditions, and may be used to predict prognosis and response to treatments in some cancers including OC. This review summarizes the current progresses regarding the potential applications of circulating miRNA as innovative biomarkers in OC.Entities:
Keywords: Biomarker; Circulating microRNA; Extracellular microRNA; Ovarian cancer
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Year: 2020 PMID： 32428568 DOI： 10.1016/j.biocel.2020.105765
Source DB: PubMed Journal: Int J Biochem Cell Biol ISSN： 1357-2725 Impact factor: 5.085