Angelo Bianchetti 1,2 , R Rozzini 3,2 , F Guerini 1,2 , S Boffelli 3,2 , P Ranieri 1,2 , G Minelli 1,2 , L Bianchetti 4,2 , M Trabucchi 2 Show Affiliations »
Abstract
Objective: No studies analyzing the role of dementia as a risk factor for mortality in patients affected by COVID-19. We assessed the prevalence, clinical presentation and outcomes of dementia among subjects hospitalized for COVID19 infection. Design: Retrospective study. Setting: COVID wards in Acute Hospital in Brescia province, Northern Italy. Participants: We used data from 627 subjects admitted to Acute Medical wards with COVID 19 pneumonia. Measurements: Clinical records of each patients admitted to the hospital with a diagnosis of COVID19 infection were retrospectively analyzed. Diagnosis of dementia, modalities of onset of the COVID-19 infection, symptoms of presentation at the hospital and outcomes were recorded. Results: Dementia was diagnosed in 82 patients (13.1%). The mortality rate was 62.2% (51/82) among patients affected by dementia compared to 26.2% (143/545) in subjects without dementia (p<0.001, Chi-Squared test). In a logistic regression model age, and the diagnosis of dementia resulted independently associated with a higher mortality, and patients diagnosed with dementia presented an OR of 1.84 (95% CI: 1.09-3.13, p<0.05). Among patients diagnosed with dementia the most frequent symptoms of onset were delirium, especially in the hypoactive form, and worsening of the functional status. Conclusion: The diagnosis of dementia, especially in the most advanced stages, represents an important risk factor for mortality in COVID-19 patients. The clinical presentation of COVID-19 in subjects with dementia is atypical, reducing early recognition of symptoms and hospitalization. © Serdi and Springer-Verlag International SAS, part of Springer Nature 2020.
Objective: No studies analyzing the role of dementia as a risk factor for mortality in patients affected by COVID-19. We assessed the prevalence, clinical presentation and outcomes of dementia among subjects hospitalized for COVID19 infection. Design: Retrospective study. Setting: COVID wards in Acute Hospital in Brescia province, Northern Italy. Participants: We used data from 627 subjects admitted to Acute Medical wards with COVID 19 pneumonia. Measurements: Clinical records of each patients admitted to the hospital with a diagnosis of COVID19 infection were retrospectively analyzed. Diagnosis of dementia, modalities of onset of the COVID-19 infection, symptoms of presentation at the hospital and outcomes were recorded. Results: Dementia was diagnosed in 82 patients (13.1%). The mortality rate was 62.2% (51/82) among patients affected by dementia compared to 26.2% (143/545) in subjects without dementia (p<0.001, Chi-Squared test). In a logistic regression model age, and the diagnosis of dementia resulted independently associated with a higher mortality, and patients diagnosed with dementia presented an OR of 1.84 (95% CI: 1.09-3.13, p<0.05). Among patients diagnosed with dementia the most frequent symptoms of onset were delirium, especially in the hypoactive form, and worsening of the functional status. Conclusion: The diagnosis of dementia, especially in the most advanced stages, represents an important risk factor for mortality in COVID-19 patients. The clinical presentation of COVID-19 in subjects with dementia is atypical, reducing early recognition of symptoms and hospitalization. © Serdi and Springer-Verlag International SAS, part of Springer Nature 2020.
Keywords:
COVID19 infection; dementia; mortality risk
Year: 2020
PMID： 32425646 PMCID： PMC7227170 DOI： 10.1007/s12603-020-1389-1
Source DB: PubMed Journal: J Nutr Health Aging ISSN： 1279-7707 Impact factor: 4.075