ZhongHua Lei1,2, Liu Ouyang3, Yong Gong1, ZhaoZhen Wang1, Bo Yu1. 1. Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, People's Republic of China. 2. Department of Orthopedics, The Sixth Peoples Hospital of Huizhou, Huizhou 516211, People's Republic of China. 3. Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China.
Abstract
PURPOSE: The aim of the experiment was to explore the effect of eriodictyol (ERI) on arthritis. METHODS: We established a rat model of collagen-induced rheumatoid arthritis (CIA) using type II collagen plus Freund's complete adjuvant. We evaluated the degree of paw swelling, joint pathology, inflammatory cytokine levels, and the Akt/hypoxia-inducible factor (HIF)-1α signaling pathway in the CIA rats. RESULTS: ERI significantly ameliorated joint swelling; improved joint pathology; and suppressed the release of interleukin-6, interleukin-1 beta, and tumor necrosis factor-alpha. Moreover, ERI inhibited the Akt/HIF-1α pathway in the joints of rats and in lipopolysaccharide-treated RAW264.7 cells. CONCLUSION: ERI ameliorated arthritis in a manner involving the Akt/HIF-1α signaling pathway.
PURPOSE: The aim of the experiment was to explore the effect of eriodictyol (ERI) on arthritis. METHODS: We established a rat model of collagen-induced rheumatoid arthritis (CIA) using type II collagen plus Freund's complete adjuvant. We evaluated the degree of paw swelling, joint pathology, inflammatory cytokine levels, and the Akt/hypoxia-inducible factor (HIF)-1α signaling pathway in the CIA rats. RESULTS: ERI significantly ameliorated joint swelling; improved joint pathology; and suppressed the release of interleukin-6, interleukin-1 beta, and tumor necrosis factor-alpha. Moreover, ERI inhibited the Akt/HIF-1α pathway in the joints of rats and in lipopolysaccharide-treated RAW264.7 cells. CONCLUSION: ERI ameliorated arthritis in a manner involving the Akt/HIF-1α signaling pathway.
Authors: Marion Scharte; Xianonan Han; Takashi Uchiyama; Zakaria Tawadrous; Russell L Delude; Mitchell P Fink Journal: J Surg Res Date: 2006-08-23 Impact factor: 2.192
Authors: J K Franz; S A Kolb; K M Hummel; F Lahrtz; M Neidhart; W K Aicher; T Pap; R E Gay; A Fontana; S Gay Journal: Eur J Immunol Date: 1998-09 Impact factor: 5.532