Alberto Rodríguez-Quiroga1,2, Karina S MacDowell3,4,5, Juan C Leza3,4,5, José Luis Carrasco6,3,7, Marina Díaz-Marsá6,3,7. 1. Department of Psychiatry, Hospital Universitario Infanta Leonor, Gran Vía del Este 80, 28030, Madrid, Spain. alberto_rodriguezquiroga@yahoo.com. 2. Department of Psychiatry and Psychology, Medical School, Complutense University, Av. Séneca, 2, 28040, Madrid, Spain. alberto_rodriguezquiroga@yahoo.com. 3. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain. 4. Department of Pharmacology, Medical School, Complutense University, Av. Séneca, 2, 28040, Madrid, Spain. 5. Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Av. Cordoba, s/n, 28041, Madrid, Spain. 6. Department of Psychiatry and Psychology, Medical School, Complutense University, Av. Séneca, 2, 28040, Madrid, Spain. 7. Department of Psychiatry, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC), Hospital Clínico San Carlos, Calle del Prof Martín Lagos, s/n, 28040, Madrid, Spain.
Abstract
PURPOSE: There is a significant relationship between childhood trauma and the development of an eating disorder in adolescence or adulthood, possibly influenced by circulating levels of inflammatory parameters. The main objective is to identify and describe a subgroup of patients with eating disorders and a history of trauma in childhood or adolescence with differential clinical features. METHODS: An observational study on a sample of 55 patients who met the diagnostic criteria for any DSM-5 eating disorder was carried out. Inflammatory parameters in white blood cells were examined. Patients underwent different assessments, including clinical and personality scales. RESULTS: Patients with a history of trauma had higher scores in the delirious and narcissistic items of the Millon Clinical Multiaxial Inventory (MCMI-II) (p < 0.05) and a higher score in the paranoid item of the SCID-5 Personality Disorders Version (SCID-5-PD) (p < 0.05). Patients with distinguishing personality features were grouped according to the Childhood Trauma Questionnaire sexual subscale. Tumor necrosis alpha (TNF-α) showed a significant association with childhood trauma history. CONCLUSIONS: There is a profile of patients with eating disorders who have increased activity in the inflammatory pathways that, if identified precociously, can benefit from specifically aimed interventions. LEVEL OF EVIDENCE: Level V, observational study.
PURPOSE: There is a significant relationship between childhood trauma and the development of an eating disorder in adolescence or adulthood, possibly influenced by circulating levels of inflammatory parameters. The main objective is to identify and describe a subgroup of patients with eating disorders and a history of trauma in childhood or adolescence with differential clinical features. METHODS: An observational study on a sample of 55 patients who met the diagnostic criteria for any DSM-5 eating disorder was carried out. Inflammatory parameters in white blood cells were examined. Patients underwent different assessments, including clinical and personality scales. RESULTS:Patients with a history of trauma had higher scores in the delirious and narcissistic items of the Millon Clinical Multiaxial Inventory (MCMI-II) (p < 0.05) and a higher score in the paranoid item of the SCID-5 Personality Disorders Version (SCID-5-PD) (p < 0.05). Patients with distinguishing personality features were grouped according to the Childhood Trauma Questionnaire sexual subscale. Tumor necrosis alpha (TNF-α) showed a significant association with childhood trauma history. CONCLUSIONS: There is a profile of patients with eating disorders who have increased activity in the inflammatory pathways that, if identified precociously, can benefit from specifically aimed interventions. LEVEL OF EVIDENCE: Level V, observational study.
Entities:
Keywords:
Adult survivors of child adverse events; Anorexia nervosa; Child abuse; Feeding and eating disorders; Tumor necrosis factor-alpha
Authors: Dianne Neumark-Sztainer; Michael P Levine; Susan J Paxton; Linda Smolak; Niva Piran; Eleanor H Wertheim Journal: Eat Disord Date: 2006 Jul-Sep Impact factor: 3.222
Authors: S A Wonderlich; R D Crosby; J E Mitchell; K M Thompson; J Redlin; G Demuth; J Smyth; B Haseltine Journal: Int J Eat Disord Date: 2001-12 Impact factor: 4.861
Authors: Andrea Poyastro Pinheiro; Cynthia M Bulik; Laura M Thornton; Patrick F Sullivan; Tammy L Root; Cinnamon S Bloss; Wade H Berrettini; Nicholas J Schork; Walter H Kaye; Andrew W Bergen; Pierre Magistretti; Harry Brandt; Steve Crawford; Scott Crow; Manfred M Fichter; David Goldman; Katherine A Halmi; Craig Johnson; Allan S Kaplan; Pamela K Keel; Kelly L Klump; Maria La Via; James E Mitchell; Michael Strober; Alessandro Rotondo; Janet Treasure; D Blake Woodside Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2010-07 Impact factor: 3.568
Authors: Lauren Reba; Laura Thornton; Federica Tozzi; Kelly L Klump; Harry Brandt; Steve Crawford; Scott Crow; Manfred M Fichter; Katherine A Halmi; Craig Johnson; Allan S Kaplan; Pamela Keel; Maria LaVia; James Mitchell; Michael Strober; D Blake Woodside; Alessandro Rotondo; Wade H Berrettini; Walter H Kaye; Cynthia M Bulik Journal: Int J Eat Disord Date: 2005-12 Impact factor: 4.861
Authors: Cynthia M Bulik; Patrick F Sullivan; Federica Tozzi; Helena Furberg; Paul Lichtenstein; Nancy L Pedersen Journal: Arch Gen Psychiatry Date: 2006-03
Authors: Azadeh A Rikani; Zia Choudhry; Adnan M Choudhry; Huma Ikram; Muhammad W Asghar; Dilkash Kajal; Abdul Waheed; Nusrat J Mobassarah Journal: Ann Neurosci Date: 2013-10