Literature DB >> 32423951

Transcriptional Inhibition of the F1F0-Type ATP Synthase Has Bactericidal Consequences on the Viability of Mycobacteria.

Matthew B McNeil1,2, Heath W K Ryburn3, Liam K Harold3,2, Justin F Tirados3, Gregory M Cook3,2.   

Abstract

Bedaquiline, an inhibitor of the mycobacterial ATP synthase, has revolutionized the treatment of Mycobacterium tuberculosis infection. Although a potent inhibitor, it is characterized by poorly understood delayed time-dependent bactericidal activity. Here, we demonstrate that in contrast to bedaquiline, the transcriptional inhibition of the ATP synthase in M. tuberculosis and Mycobacterium smegmatis has rapid bactericidal activity. These results validate the mycobacterial ATP synthase as a drug target with the potential for rapid bactericidal activity.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  ATP synthase; CRISPRi; tuberculosis

Mesh：

Substances：

Year:  2020        PMID： 32423951      PMCID： PMC7526845          DOI： 10.1128/AAC.00492-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Susceptibility testing: accurate and reproducible minimum inhibitory concentration (MIC) and non-inhibitory concentration (NIC) values.

Authors:  R J Lambert; J Pearson
Journal:  J Appl Microbiol       Date:  2000-05       Impact factor: 3.772

2.  A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis.

Authors:  Koen Andries; Peter Verhasselt; Jerome Guillemont; Hinrich W H Göhlmann; Jean-Marc Neefs; Hans Winkler; Jef Van Gestel; Philip Timmerman; Min Zhu; Ennis Lee; Peter Williams; Didier de Chaffoy; Emma Huitric; Sven Hoffner; Emmanuelle Cambau; Chantal Truffot-Pernot; Nacer Lounis; Vincent Jarlier
Journal:  Science       Date:  2004-12-09       Impact factor: 47.728

3.  Utilization of CRISPR Interference To Validate MmpL3 as a Drug Target in Mycobacterium tuberculosis.

Authors:  Matthew B McNeil; Gregory M Cook
Journal:  Antimicrob Agents Chemother       Date:  2019-07-25       Impact factor: 5.191

4.  Ionophoric effects of the antitubercular drug bedaquiline.

Authors:  Kiel Hards; Duncan G G McMillan; Lici A Schurig-Briccio; Robert B Gennis; Holger Lill; Dirk Bald; Gregory M Cook
Journal:  Proc Natl Acad Sci U S A       Date:  2018-06-25       Impact factor: 11.205

5.  Regulation of proline metabolism in mycobacteria and its role in carbon metabolism under hypoxia.

Authors:  Michael Berney; Marion R Weimar; Adam Heikal; Gregory M Cook
Journal:  Mol Microbiol       Date:  2012-04-16       Impact factor: 3.501

6.  Genes required for mycobacterial growth defined by high density mutagenesis.

Authors:  Christopher M Sassetti; Dana H Boyd; Eric J Rubin
Journal:  Mol Microbiol       Date:  2003-04       Impact factor: 3.501

7.  Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism.

Authors:  Anil Koul; Luc Vranckx; Neeraj Dhar; Hinrich W H Göhlmann; Emre Özdemir; Jean-Marc Neefs; Melanie Schulz; Ping Lu; Ejvind Mørtz; John D McKinney; Koen Andries; Dirk Bald
Journal:  Nat Commun       Date:  2014-02-26       Impact factor: 14.919

8.  Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform.

Authors:  Jeremy M Rock; Forrest F Hopkins; Alejandro Chavez; Marieme Diallo; Michael R Chase; Elias R Gerrick; Justin R Pritchard; George M Church; Eric J Rubin; Christopher M Sassetti; Dirk Schnappinger; Sarah M Fortune
Journal:  Nat Microbiol       Date:  2017-02-06       Impact factor: 17.745

9.  Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis.

Authors:  Michael A DeJesus; Elias R Gerrick; Weizhen Xu; Sae Woong Park; Jarukit E Long; Cara C Boutte; Eric J Rubin; Dirk Schnappinger; Sabine Ehrt; Sarah M Fortune; Christopher M Sassetti; Thomas R Ioerger
Journal:  MBio       Date:  2017-01-17       Impact factor: 7.867

10.  Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis.

Authors:  Wuan-Geok Saw; Mu-Lu Wu; Priya Ragunathan; Goran Biuković; Aik-Meng Lau; Joon Shin; Amaravadhi Harikishore; Chen-Yi Cheung; Kiel Hards; Jickky Palmae Sarathy; Roderick W Bates; Gregory M Cook; Thomas Dick; Gerhard Grüber
Journal:  Sci Rep       Date:  2019-11-14       Impact factor: 4.379
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  9 in total

1.  Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline.

Authors:  Hui Guo; Gautier M Courbon; Stephanie A Bueler; Juntao Mai; Jun Liu; John L Rubinstein
Journal:  Nature       Date:  2020-12-09       Impact factor: 49.962

Review 2.  CRISPR-Based Approaches for Gene Regulation in Non-Model Bacteria.

Authors:  Stephanie N Call; Lauren B Andrews
Journal:  Front Genome Ed       Date:  2022-06-23

Review 3.  The genetic proteome: Using genetics to inform the proteome of mycobacterial pathogens.

Authors:  Kathleen R Nicholson; C Bruce Mousseau; Matthew M Champion; Patricia A Champion
Journal:  PLoS Pathog       Date:  2021-01-07       Impact factor: 6.823

4.  An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis.

Authors:  Kiel Hards; Chen-Yi Cheung; Natalie Waller; Cara Adolph; Laura Keighley; Zhi Shean Tee; Liam K Harold; Ayana Menorca; Richard S Bujaroski; Benjamin J Buckley; Joel D A Tyndall; Matthew B McNeil; Kyu Y Rhee; Helen K Opel-Reading; Kurt Krause; Laura Preiss; Julian D Langer; Thomas Meier; Erik J Hasenoehrl; Michael Berney; Michael J Kelso; Gregory M Cook
Journal:  Commun Biol       Date:  2022-02-24

5.  Multiplexed transcriptional repression identifies a network of bactericidal interactions between mycobacterial respiratory complexes.

Authors:  Matthew B McNeil; Heath W Ryburn; Justin Tirados; Chen-Yi Cheung; Gregory M Cook
Journal:  iScience       Date:  2021-12-04

Review 6.  Uncovering interactions between mycobacterial respiratory complexes to target drug-resistant Mycobacterium tuberculosis.

Authors:  Matthew B McNeil; Chen-Yi Cheung; Natalie J E Waller; Cara Adolph; Cassandra L Chapman; Noon E J Seeto; William Jowsey; Zhengqiu Li; H M Adnan Hameed; Tianyu Zhang; Gregory M Cook
Journal:  Front Cell Infect Microbiol       Date:  2022-08-24       Impact factor: 6.073

7.  Impaired Succinate Oxidation Prevents Growth and Influences Drug Susceptibility in Mycobacterium tuberculosis.

Authors:  Cara Adolph; Matthew B McNeil; Gregory M Cook
Journal:  mBio       Date:  2022-07-20       Impact factor: 7.786

8.  Binding properties of the anti-TB drugs bedaquiline and TBAJ-876 to a mycobacterial F-ATP synthase.

Authors:  Alexander Krah; Gerhard Grüber; Peter J Bond
Journal:  Curr Res Struct Biol       Date:  2022-09-09

9.  Deciphering functional redundancy and energetics of malate oxidation in mycobacteria.

Authors:  Liam K Harold; Adrian Jinich; Kiel Hards; Alexandra Cordeiro; Laura M Keighley; Alec Cross; Matthew B McNeil; Kyu Rhee; Gregory M Cook
Journal:  J Biol Chem       Date:  2022-03-23       Impact factor: 5.486
  9 in total

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