Marzia Vasarri1, Emanuela Barletta2, Matteo Ramazzotti3, Donatella Degl'Innocenti4. 1. Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134, Florence, Italy. Electronic address: marzia.vasarri@unifi.it. 2. Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134, Florence, Italy. Electronic address: emanuela.barletta@unifi.it. 3. Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134, Florence, Italy. Electronic address: matteo.ramazzotti@unifi.it. 4. Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134, Florence, Italy; Italy Interuniversity Center of Marine Biology and Applied Ecology "G. Bacci" (CIBM), Viale N. Sauro 4, 57128, Leghorn, Italy. Electronic address: donatella.deglinnocenti@unifi.it.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: The marine plant Posidonia oceanica (L.) Delile is traditionally used by villagers of the west coast of Anatolia as a remedy for diabetes and hypertension. AIM OF THE STUDY: The aim of this study was to explore the role of the P. oceanica hydroalcoholic leaves extract (POE) against human serum albumin glycation. MATERIAL AND METHODS: Advanced glycation end products (AGEs) were obtained with the albumin-glucose in vitro assay. The AGEs intrinsic fluorescence intensity and the electrophoretic migration under native conditions allowed us to verify the effective glycation of albumin. The presence of POE during glycation process was intended to evaluate its anti-glycation role. RESULTS: POE exhibited a strong in vitro anti-glycation ability which occurred independently from its known antioxidant property. CONCLUSIONS: Overall, the antidiabetic, antioxidant, anti-inflammatory and anti-glycation properties of POE could be exploited as an effective tool against diabetes and related complications.
ETHNOPHARMACOLOGICAL RELEVANCE: The marine plant Posidonia oceanica (L.) Delile is traditionally used by villagers of the west coast of Anatolia as a remedy for diabetes and hypertension. AIM OF THE STUDY: The aim of this study was to explore the role of the P. oceanica hydroalcoholic leaves extract (POE) against human serum albumin glycation. MATERIAL AND METHODS: Advanced glycation end products (AGEs) were obtained with the albumin-glucose in vitro assay. The AGEs intrinsic fluorescence intensity and the electrophoretic migration under native conditions allowed us to verify the effective glycation of albumin. The presence of POE during glycation process was intended to evaluate its anti-glycation role. RESULTS:POE exhibited a strong in vitro anti-glycation ability which occurred independently from its known antioxidant property. CONCLUSIONS: Overall, the antidiabetic, antioxidant, anti-inflammatory and anti-glycation properties of POE could be exploited as an effective tool against diabetes and related complications.
Authors: Laura Micheli; Marzia Vasarri; Emanuela Barletta; Elena Lucarini; Carla Ghelardini; Donatella Degl'Innocenti; Lorenzo Di Cesare Mannelli Journal: Mar Drugs Date: 2021-01-21 Impact factor: 5.118
Authors: Marzia Vasarri; Anna Maria De Biasi; Emanuela Barletta; Carlo Pretti; Donatella Degl'Innocenti Journal: Mar Drugs Date: 2021-08-25 Impact factor: 5.118