Preparation and characterization of borosilicate bioglass incorporated sodium alginate composite wound dressing for accelerated full-thickness skin wound healing.

Full-thickness skin injury is a serious and intractable clinical problem. Wound dressing is urgently needed to treat serious skin defects or induce skin reconstruction. For the first time, we demonstrated a borosilicate bioglass (BBG) incorporated sodium alginate (SA) wound dressing by a simple and effective technique for accelerated wound healing. The physical and chemical properties, in vitro and in vivo properties of SA-BBG composite wound dressing have been investigated. The results show that the SA-BBG composite dressing possess good water absorption performance. Boron ions and silicon ions in borosilicate bioglass can maintain stable and sustained release. Most importantly, SA-BBG composite wound dressing shows outstanding wound healing ability in full-thickness skin defects in rats. The wounds were treated with SA-BBG composite dressing groups had almost closed at day 15. When the ratio of sodium alginate to bioglass in the sponge is 3:1, the wound healing effect is the best. In conclusion, SA-BBG composite dressing shows great potential application in skin wound healing and SA3BBG works best.