Literature DB >> 3242176

Sterols of Acanthamoeba culbertsoni strain A-1.

H Mehdi1, H S Garg, N K Garg, D S Bhakuni.   

Abstract

Two new sterols, stigmasta-5,7,22,25-tetraene-3 beta -ol (1) and stigmasta-5,7,14,22,25-pentaene-3 beta -ol (2), have been characterized along with ergosterol and 7-dehydrostigmasterol in the nonsaponifiable fraction of the total lipids extracted from trophozoites of Acanthamoeba culbertsoni strain A-1 (virulent strain). However, these sterols were found to be absent in the nonpathogenic strain C-7 of A. culbertsoni.

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Year:  1988        PMID： 3242176     DOI： 10.1016/0039-128x(88)90051-7

Source DB:  PubMed          Journal:  Steroids        ISSN： 0039-128X            Impact factor:   2.668


  8 in total

1.  Statins and voriconazole induce programmed cell death in Acanthamoeba castellanii.

Authors:  Carmen M Martín-Navarro; Atteneri López-Arencibia; Ines Sifaoui; María Reyes-Batlle; Basilio Valladares; Enrique Martínez-Carretero; José E Piñero; Sutherland K Maciver; Jacob Lorenzo-Morales
Journal:  Antimicrob Agents Chemother       Date:  2015-03-02       Impact factor: 5.191

2.  Evaluation of the in vitro activity of commercially available moxifloxacin and voriconazole eye-drops against clinical strains of Acanthamoeba.

Authors:  C M Martín-Navarro; A López-Arencibia; F Arnalich-Montiel; B Valladares; J E Piñero; J Lorenzo-Morales
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2013-05-19       Impact factor: 3.117

3.  In vitro evaluation of the amebicidal activity of Pterocaulon polystachyum (Asteraceae) against trophozoites of Acanthamoeba castellanii.

Authors:  Camila Ródio; Damiana da Rocha Vianna; Kreesla Passos Kowalski; Lua Ferreira Panatieri; Gilsane von Poser; Marilise Brittes Rott
Journal:  Parasitol Res       Date:  2008-09-16       Impact factor: 2.289

4.  Voriconazole as a first-line treatment against potentially pathogenic Acanthamoeba strains from Peru.

Authors:  Alfonso Martín Cabello-Vílchez; Carmen M Martín-Navarro; Atteneri López-Arencibia; María Reyes-Batlle; Ines Sifaoui; Basilio Valladares; José E Piñero; Jacob Lorenzo-Morales
Journal:  Parasitol Res       Date:  2013-11-22       Impact factor: 2.289

5.  Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and application of statins as a novel effective therapeutic approach against Acanthamoeba infections.

Authors:  Carmen María Martín-Navarro; Jacob Lorenzo-Morales; Rubén P Machin; Atteneri López-Arencibia; José Manuel García-Castellano; Isabel de Fuentes; Brendan Loftus; Sutherland K Maciver; Basilio Valladares; José E Piñero
Journal:  Antimicrob Agents Chemother       Date:  2012-10-31       Impact factor: 5.191

6.  Functional importance for developmental regulation of sterol biosynthesis in Acanthamoeba castellanii.

Authors:  Wenxu Zhou; Andrew G S Warrilow; Crista D Thomas; Emilio Ramos; Josie E Parker; Claire L Price; Boden H Vanderloop; Paxtyn M Fisher; Michael D Loftis; Diane E Kelly; Steven L Kelly; W David Nes
Journal:  Biochim Biophys Acta Mol Cell Biol Lipids       Date:  2018-07-22       Impact factor: 4.698

7.  Sterol methyltransferase a target for anti-amoeba therapy: towards transition state analog and suicide substrate drug design.

Authors:  Medhanie E Kidane; Boden H Vanderloop; Wenxu Zhou; Crista D Thomas; Emilio Ramos; Ujjal Singha; Minu Chaudhuri; W David Nes
Journal:  J Lipid Res       Date:  2017-10-17       Impact factor: 5.922

8.  Characterisation of sterol biosynthesis and validation of 14α-demethylase as a drug target in Acanthamoeba.

Authors:  Scott Thomson; Christopher A Rice; Tong Zhang; RuAngelie Edrada-Ebel; Fiona L Henriquez; Craig W Roberts
Journal:  Sci Rep       Date:  2017-08-15       Impact factor: 4.379
  8 in total

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