Masoumeh Ghafarzadeh1, Amir Shakarami2, Fatemeh Yari3, Parsa Namdari4. 1. Department of Obstetrics and Gynecology, School of Medicine, Lorestan University of Medical Sciences , Khorramabad, Iran. 2. Department of Cardiology, School of Medicine, Lorestan University of Medical Sciences , Khorramabad, Iran. 3. Department of Reproductive Health, Lorestan University of Medical Sciences , Khorramabad, Iran. 4. Department of Medicine, University of Debrecen , Hungary.
Abstract
OBJECTIVE: The aim of the study was to compare the complication of Antihypertensive drug; in pregnant women with chronic hypertension. METHOD: This retrospective cohort study was performed on 300 pregnant women with chronic hypertension. Results: a relative risk of preeclampsia among methyldopa group was 3.45 times higher than the metoprolol, the relative risk of preterm labor was not significantly between methyldopa and metoprolol group, LBW, and IUGR in methyldopa and amlodipine groups . CONCLUSION: Methyldopa and amlodipine are associated with the least side effects in pregnant women treated for chronic hypertension.the incidence of preeclampsia was greater in methyldopa group.
OBJECTIVE: The aim of the study was to compare the complication of Antihypertensive drug; in pregnant women with chronic hypertension. METHOD: This retrospective cohort study was performed on 300 pregnant women with chronic hypertension. Results: a relative risk of preeclampsia among methyldopa group was 3.45 times higher than the metoprolol, the relative risk of preterm labor was not significantly between methyldopa and metoprolol group, LBW, and IUGR in methyldopa and amlodipine groups . CONCLUSION:Methyldopa and amlodipine are associated with the least side effects in pregnant women treated for chronic hypertension.the incidence of preeclampsia was greater in methyldopa group.
Entities:
Keywords:
Pregnancy; adverse drug effects; chronic hypertension; fetal and neonatal outcomes; maternal outcomes; methyldopa; metoprolol