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Literature DB >> 32420537

Prominent effect of platelet on improvement of liver cirrhosis.

Hui Xu^1,2, Xiao-Meng Jiang^3,4, Ying Wu³, Yu-Mei Li^1,2, Yun-Wen Zheng^1,5,6,7, Nobuhiro Ohkohchi⁶.

Abstract

Thrombopoietin (TPO) can improve liver regeneration and fibrosis. We report on a patient with liver cirrhosis who received treatment with TPO to improve liver function. An 82-year-old male had liver cirrhosis with ascites due to hepatitis C virus infection. The Child-Pugh classification was Child B. The patient received human recombinant TPO for 12 months. The platelet counts increased and were maintained at 60-80×109/L. The liver function improved, the ascites resolved, and the liver volume increased. These results indicate that the novel treatment with recombinant human TPO (rhTPO) may be effective for improving liver function in patients with liver cirrhosis. 2020 AME Case Reports. All rights reserved.

Entities: Disease Gene Species

Keywords: Liver cirrhosis; case report; liver function; platelet; thrombopoietin (TPO)

Year: 2020 PMID： 32420537 PMCID： PMC7225403 DOI： 10.21037/acr.2020.04.02

Source DB: PubMed Journal: AME Case Rep ISSN： 2523-1995

15 in total

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Authors: Zhangyuan Kong; Ping Qin; Shan Xiao; Hai Zhou; Hong Li; Renchi Yang; Xiaofan Liu; Jianmin Luo; Zhichun Li; Guochao Ji; Zhongguang Cui; Yusheng Bai; Yuxia Wu; Linlin Shao; Jun Peng; Jun Ma; Ming Hou
Journal: Blood Date: 2017-06-19 Impact factor: 22.113

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Journal: Vaccine Date: 2012-01-24 Impact factor: 3.641

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Authors: Tomohiro Kurokawa; Soichiro Murata; Nobuhiro Ohkohchi
Journal: Tohoku J Exp Med Date: 2016-12 Impact factor: 1.848

4. Thrombopoietin induces rapid resolution of thrombocytopenia after orthotopic liver transplantation through increased platelet production.

Authors: M Peck-Radosavljevic; M Wichlas; J Zacherl; G Stiegler; P Stohlawetz; M Fuchsjäger; A Kreil; S Metz-Schimmerl; S Panzer; R Steininger; F Mühlbacher; P Ferenci; J Pidlich; A Gangl
Journal: Blood Date: 2000-02-01 Impact factor: 22.113

5. Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice.

Authors: Isao Sakaida; Shuji Terai; Naoki Yamamoto; Koji Aoyama; Tsuyoshi Ishikawa; Hiroshi Nishina; Kiwamu Okita
Journal: Hepatology Date: 2004-12 Impact factor: 17.425

6. Platelet administration via the portal vein promotes liver regeneration in rats after 70% hepatectomy.

Authors: Ryota Matsuo; Yoritaka Nakano; Nobuhiro Ohkohchi
Journal: Ann Surg Date: 2011-04 Impact factor: 12.969

7. Effects of thrombopoietin on growth of hepatocellular carcinoma: Is thrombopoietin therapy for liver disease safe or not?

Authors: Reiji Nozaki; Soichiro Murata; Takeshi Nowatari; Takehito Maruyama; Naoya Ikeda; Takuya Kawasaki; Kiyoshi Fukunaga; Nobuhiro Ohkohchi
Journal: Hepatol Res Date: 2012-11-16 Impact factor: 4.288

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Authors: Jia Fan; Guang-Shun Yang; Zhi-Ren Fu; Zhi-Hai Peng; Qiang Xia; Chen-Hong Peng; Jian-Ming Qian; Jian Zhou; Yang Xu; Shuang-Jian Qiu; Lin Zhong; Guang-Wen Zhou; Jian-Jun Zhang
Journal: J Cancer Res Clin Oncol Date: 2009-04-21 Impact factor: 4.553