Yuzhuo Fan1, Zekuan Yu2, Zisu Peng1, Qiong Xu1, Tao Tang1, Kai Wang3, Qiushi Ren4, Mingwei Zhao1, Jia Qu5. 1. Department of Ophthalmology & Clinical Center of Optometry, Peking University People's Hospital, Beijing 100044, China; College of Optometry, Peking University Health Science Center, Beijing, China; Eye Disease and Optometry Institute, Peking University People's Hospital, China; Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, China. 2. Academy for Engineering & Technology, Fudan University, China; Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China. 3. Department of Ophthalmology & Clinical Center of Optometry, Peking University People's Hospital, Beijing 100044, China; College of Optometry, Peking University Health Science Center, Beijing, China; Eye Disease and Optometry Institute, Peking University People's Hospital, China; Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, China. Electronic address: wang_kai@263.net. 4. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China. 5. College of Optometry, Peking University Health Science Center, Beijing, China; School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, China.
Abstract
PURPOSE: Return zone depth (RZD) and landing zone angle (LZA) are important parameters of corneal refractive therapy (CRT) lenses. A new machine learning algorithm is proposed for prescribing CRT lens parameters in Chinese adolescents with myopia. METHODS: This is a retrospective study. In total, 1037 Chinese adolescents with myopia (1037 right eyes) were enrolled. A calculation model based on corneal elevation maps was constructed to calculate RZD and LZA for the four quadrants. Furthermore, multiple linear regression and optimized machine learning models were established to predict RZD and LZA values for different combinations of age, sex, and ocular parameters. The four methods (sliding card, linear regression, calculation and optimized machine learning) were then compared to the parameters of the final ordered lens. RESULTS: The optimized machine learning pipeline achieved the best performance. Age, sex, horizontal visible iris diameter (HVID), spherical equivalent refraction degree (SER), eccentricity (e), keratometric (K) readings, corneal astigmatism (CA), axial length (AL), AL/corneal curvature ratio (AL/MK), and anterior chamber depth (ACD) were significant to the machine learning model. The R values for the nasal, temporal, superior and inferior LZA based on machine learning were 0.843, 0.693, 0.866 and 0.762, respectively, and those for the RZD were 0.970, 0.964, 0.975 and 0.964, respectively. CONCLUSIONS: The feasibility and efficiency of an optimized machine learning method to predict LZA and RZD parameters has been demonstrated. The advantage of the proposed method is that it is more accurate, easier to use and faster to implement than the traditional sliding card method.
PURPOSE: Return zone depth (RZD) and landing zone angle (LZA) are important parameters of corneal refractive therapy (CRT) lenses. A new machine learning algorithm is proposed for prescribing CRT lens parameters in Chinese adolescents with myopia. METHODS: This is a retrospective study. In total, 1037 Chinese adolescents with myopia (1037 right eyes) were enrolled. A calculation model based on corneal elevation maps was constructed to calculate RZD and LZA for the four quadrants. Furthermore, multiple linear regression and optimized machine learning models were established to predict RZD and LZA values for different combinations of age, sex, and ocular parameters. The four methods (sliding card, linear regression, calculation and optimized machine learning) were then compared to the parameters of the final ordered lens. RESULTS: The optimized machine learning pipeline achieved the best performance. Age, sex, horizontal visible iris diameter (HVID), spherical equivalent refraction degree (SER), eccentricity (e), keratometric (K) readings, corneal astigmatism (CA), axial length (AL), AL/corneal curvature ratio (AL/MK), and anterior chamber depth (ACD) were significant to the machine learning model. The R values for the nasal, temporal, superior and inferior LZA based on machine learning were 0.843, 0.693, 0.866 and 0.762, respectively, and those for the RZD were 0.970, 0.964, 0.975 and 0.964, respectively. CONCLUSIONS: The feasibility and efficiency of an optimized machine learning method to predict LZA and RZD parameters has been demonstrated. The advantage of the proposed method is that it is more accurate, easier to use and faster to implement than the traditional sliding card method.
Authors: Shi-Ming Li; Ming-Yang Ren; Jiahe Gan; San-Guo Zhang; Meng-Tian Kang; He Li; David A Atchison; Jos Rozema; Andrzej Grzybowski; Ningli Wang Journal: Ophthalmol Ther Date: 2022-01-21