Fully automatic brain tumor segmentation with deep learning-based selective attention using overlapping patches and multi-class weighted cross-entropy.

In this paper, we present a new Deep Convolutional Neural Networks (CNNs) dedicated to fully automatic segmentation of Glioblastoma brain tumors with high- and low-grade. The proposed CNNs model is inspired by the Occipito-Temporal pathway which has a special function called selective attention that uses different receptive field sizes in successive layers to figure out the crucial objects in a scene. Thus, using selective attention technique to develop the CNNs model, helps to maximize the extraction of relevant features from MRI images. We have also addressed two more issues: class-imbalance, and the spatial relationship among image Patches. To address the first issue, we propose two steps: an equal sampling of images Patches and an experimental analysis of the effect of weighted cross-entropy loss function on the segmentation results. In addition, to overcome the second issue, we have studied the effect of Overlapping Patches against Adjacent Patches where the Overlapping Patches show better segmentation results due to the introduction of the global context as well as the local features of the image Patches compared to the conventionnel Adjacent Patches. Our experiment results are reported on BRATS-2018 dataset where our End-to-End Deep Learning model achieved state-of-the-art performance. The median Dice score of our fully automatic segmentation model is 0.90, 0.83, 0.83 for the whole tumor, tumor core, and enhancing tumor respectively compared to the Dice score of radiologist, that is in the range 74% - 85%. Moreover, our proposed CNNs model is not only computationally efficient at inference time, but it could segment the whole brain on average 12 seconds. Finally, the proposed Deep Learning model provides an accurate and reliable segmentation result, and that makes it suitable for adopting in research and as a part of different clinical settings.