Mahitha Karee1, Sirisha R Gundabattula2, Latha Sashi3, Harikishan Boorugu4, Aakash Chowdhury5. 1. Affiliated to Department of Gynaecology, Fernandez Hospital, Hyderabad, India. Electronic address: drmahitha_karee@fernandez.foundation. 2. Affiliated to Department of Gynaecology, Fernandez Hospital, Hyderabad, India. Electronic address: drgsirisharao@gmail.com. 3. Affiliated to Department of Clinical Nutrition & Dietetics, Fernandez Hospital, Hyderabad, India. Electronic address: drlatha_s@fernandez.foundation. 4. Affiliated to Department of Obstetric Medicine, Fernandez Hospital, Hyderabad, India. Electronic address: drharikishan.b@fernandez.foundation. 5. Affiliated to Department of Biostatistics, Fernandez Hospital, Hyderabad, India. Electronic address: aakash140494@gmail.com.
Abstract
BACKGROUND AND AIMS: Metabolic syndrome (MetS) and polycystic ovary syndrome (PCOS) are two interrelated but distinct endocrine problems with several health consequences secondary to insulin resistance. This study aimed to determine the prevalence of MetS in women with PCOS. METHODS: This was a cross sectional study carried out from May 2017 to October 2017 at the gynecology outpatient clinic of a tertiary care private hospital in Hyderabad, India. Eligible women diagnosed with PCOS according to Rotterdam criteria were enrolled. The primary outcome was the prevalence of MetS diagnosed by the modified NCEP ATP III criteria. RESULTS: The study comprised 382 patients with a mean age of 26.8 ± 5.3 years. MetS was present in 147 (38.5%) women with PCOS. The most frequently observed individual components of MetS were increased waist circumference and decreased HDL cholesterol. When predictors for MetS were analyzed by multivariate regression, BMI (aOR 1.14; 1.06-1.23; p ≪0.001) and age (aOR 1.12; 1.06-1.17; p ≪0.001) were significantly associated with MetS; however, the effect size was modest. CONCLUSION: A high prevalence of MetS was observed in women with PCOS at this tertiary center in Hyderabad, with abdominal obesity and low HDL cholesterol as predominant components. We believe that universal screening of all PCOS women is a reasonable option.
BACKGROUND AND AIMS: Metabolic syndrome (MetS) and polycystic ovary syndrome (PCOS) are two interrelated but distinct endocrine problems with several health consequences secondary to insulin resistance. This study aimed to determine the prevalence of MetS in women with PCOS. METHODS: This was a cross sectional study carried out from May 2017 to October 2017 at the gynecology outpatient clinic of a tertiary care private hospital in Hyderabad, India. Eligible women diagnosed with PCOS according to Rotterdam criteria were enrolled. The primary outcome was the prevalence of MetS diagnosed by the modified NCEP ATP III criteria. RESULTS: The study comprised 382 patients with a mean age of 26.8 ± 5.3 years. MetS was present in 147 (38.5%) women with PCOS. The most frequently observed individual components of MetS were increased waist circumference and decreased HDL cholesterol. When predictors for MetS were analyzed by multivariate regression, BMI (aOR 1.14; 1.06-1.23; p ≪0.001) and age (aOR 1.12; 1.06-1.17; p ≪0.001) were significantly associated with MetS; however, the effect size was modest. CONCLUSION: A high prevalence of MetS was observed in women with PCOS at this tertiary center in Hyderabad, with abdominal obesity and low HDL cholesterol as predominant components. We believe that universal screening of all PCOSwomen is a reasonable option.