Jean-Benoit Martinot1, Nhat Nam Le-Dong2, Valérie Cuthbert3, Stéphane Denison2, Philip Silkoff4, Jean Christian Borel5, Jean Louis Pépin5. 1. Sleep Laboratory, CHU UCL Namur Site Sainte-Elisabeth, Belgium; Institute of Experimental and Clinical Research, UCL, Bruxelles Woluwe, Belgium. Electronic address: martinot.j@respisom.be. 2. Sunrise, Namur, Belgium. 3. Sleep Laboratory, CHU UCL Namur Site Sainte-Elisabeth, Belgium. 4. Sleep Laboratory, CHU UCL Namur Site Sainte-Elisabeth, Belgium; Institute of Experimental and Clinical Research, UCL, Bruxelles Woluwe, Belgium; Sunrise, Namur, Belgium; Université Grenoble Alpes, Inserm, CHU Grenoble Alpes, HP2, 38000 Grenoble, France. 5. Université Grenoble Alpes, Inserm, CHU Grenoble Alpes, HP2, 38000 Grenoble, France.
Abstract
RATIONALE: Mandibular position and motion during sleep rely on the balance between mandibular elevators and depressors. We hypothesized that vertical mandibular position (VMP) modulates airflow amplitude during sleep. METHODS: VMP, tidal nasal flow pressure (NFP) and concurrent surface electromyographic activity of the masseters (sEMG-m) were recorded and processed by a customized algorithm from 100 polysomnographic fragments including a micro-arousal (25 obstructive sleep apnea patients). The relationship between mandibular position and changes in airflow was analysed. RESULT: Concurrent VMP and sEMG-m activity changes routinely occurred before a new steady state of airflow documented by NFP. Vertical mandible depression was associated with a median (95% CI) reduction in NFP of 40.9% (14.6%-71.3%, p = 0.007) while vertical mandible elevation and mouth closure were associated with a median (95% CI) relative increase in NFP after arousal of 52.6% (17.9%-56.2%, p = 0.001). CONCLUSION: Elevation and lowering of the mandible were associated with changes in masseteric EMG activity modulating airflow amplitude during sleep.
RATIONALE: Mandibular position and motion during sleep rely on the balance between mandibular elevators and depressors. We hypothesized that vertical mandibular position (VMP) modulates airflow amplitude during sleep. METHODS:VMP, tidal nasal flow pressure (NFP) and concurrent surface electromyographic activity of the masseters (sEMG-m) were recorded and processed by a customized algorithm from 100 polysomnographic fragments including a micro-arousal (25 obstructive sleep apneapatients). The relationship between mandibular position and changes in airflow was analysed. RESULT: Concurrent VMP and sEMG-m activity changes routinely occurred before a new steady state of airflow documented by NFP. Vertical mandible depression was associated with a median (95% CI) reduction in NFP of 40.9% (14.6%-71.3%, p = 0.007) while vertical mandible elevation and mouth closure were associated with a median (95% CI) relative increase in NFP after arousal of 52.6% (17.9%-56.2%, p = 0.001). CONCLUSION: Elevation and lowering of the mandible were associated with changes in masseteric EMG activity modulating airflow amplitude during sleep.
Authors: Julia L Kelly; Raoua Ben Messaoud; Marie Joyeux-Faure; Robin Terrail; Renaud Tamisier; Jean-Benoît Martinot; Nhat-Nam Le-Dong; Mary J Morrell; Jean-Louis Pépin Journal: Front Neurosci Date: 2022-03-15 Impact factor: 4.677