Literature DB >> 32413294

What Makes a Discovery Successful? The Story of Linda Buck and the Olfactory Receptors.

Ann-Sophie Barwich1.   

Abstract

In 1991, Buck and Axel published a landmark study in Cell for work that was awarded the 2004 Nobel Prize. The identification of the olfactory receptors as the largest family of GPCRs catapulted olfaction into mainstream neurobiology. This BenchMark revisits Buck's experimental innovation and its surprising success at the time.
Copyright © 2020 Elsevier Inc. All rights reserved.

Keywords:  GPCRs; PCR; history of science; odor receptors; olfaction; philosophy of science; scientific discovery; scientific narratives

Mesh:

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Year:  2020        PMID: 32413294     DOI: 10.1016/j.cell.2020.04.040

Source DB:  PubMed          Journal:  Cell        ISSN: 0092-8674            Impact factor:   41.582


  2 in total

Review 1.  Odor coding in the mammalian olfactory epithelium.

Authors:  Smija M Kurian; Rafaella G Naressi; Diogo Manoel; Ann-Sophie Barwich; Bettina Malnic; Luis R Saraiva
Journal:  Cell Tissue Res       Date:  2021-01-06       Impact factor: 5.249

Review 2.  More than meets the AI: The possibilities and limits of machine learning in olfaction.

Authors:  Ann-Sophie Barwich; Elisabeth A Lloyd
Journal:  Front Neurosci       Date:  2022-09-01       Impact factor: 5.152

  2 in total

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