Literature DB >> 32413198

Pillar[n]MaxQ: A New High Affinity Host Family for Sequestration in Water.

Weijian Xue1, Peter Y Zavalij1, Lyle Isaacs1.   

Abstract

We report the synthesis, X-ray crystal structure, and molecular recognition properties of pillar[n]arene derivative P[6]AS, which we refer to as Pillar[6]MaxQ along with analogues P[5]AS and P[7]AS toward guests 1-18. The ultratight binding affinity of P[5]AS and P[6]AS toward quaternary (di)ammonium ions renders them prime candidates for in vitro and in vivo non-covalent bioconjugation, for imaging and delivery applications, and as in vivo sequestration agents.
© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  host-guest systems; neuromuscular blockers; pillararene; sequestration agent; ultratight binding

Mesh：

Substances：

Year:  2020        PMID： 32413198      PMCID： PMC7487980          DOI： 10.1002/anie.202005902

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  56 in total

1.  Cucurbituril-Based Molecular Recognition.

Authors:  Steven J Barrow; Setu Kasera; Matthew J Rowland; Jesús del Barrio; Oren A Scherman
Journal:  Chem Rev       Date:  2015-11-13       Impact factor: 60.622

2.  Desymmetrized Leaning Pillar[6]arene.

Authors:  Jia-Rui Wu; Anthony U Mu; Bao Li; Chun-Yu Wang; Lei Fang; Ying-Wei Yang
Journal:  Angew Chem Int Ed Engl       Date:  2018-07-03       Impact factor: 15.336

3.  Targeting the Cell Membrane by Charge-Reversal Amphiphilic Pillar[5]arene for the Selective Killing of Cancer Cells.

Authors:  Yincheng Chang; Jian-Yu Chen; Jinpeng Yang; Tao Lin; Lingda Zeng; Jiang-Fei Xu; Jun-Li Hou; Xi Zhang
Journal:  ACS Appl Mater Interfaces       Date:  2019-10-08       Impact factor: 9.229

4.  Revisiting the optimal c value for isothermal titration calorimetry.

Authors:  Jana Broecker; Carolyn Vargas; Sandro Keller
Journal:  Anal Biochem       Date:  2011-07-30       Impact factor: 3.365

5.  Ultrastable Artificial Binding Pairs as a Supramolecular Latching System: A Next Generation Chemical Tool for Proteomics.

Authors:  Kyeng Min Park; James Murray; Kimoon Kim
Journal:  Acc Chem Res       Date:  2017-03-21       Impact factor: 22.384

6.  A Modular Phosphorylated Glycoluril-Derived Molecular Tweezer for Potent Binding of Aliphatic Diamines.

Authors:  Michael Heilmann; Konrad Tiefenbacher
Journal:  Chemistry       Date:  2019-09-13       Impact factor: 5.236

7.  Facile, rapid, and high-yield synthesis of pillar[5]arene from commercially available reagents and its X-ray crystal structure.

Authors:  Tomoki Ogoshi; Takamichi Aoki; Keisuke Kitajima; Shuhei Fujinami; Tada-aki Yamagishi; Yoshiaki Nakamoto
Journal:  J Org Chem       Date:  2010-12-13       Impact factor: 4.354

8.  Supramolecular Explorations: Exhibiting the Extent of Extended Cationic Cyclophanes.

Authors:  Edward J Dale; Nicolaas A Vermeulen; Michal Juríček; Jonathan C Barnes; Ryan M Young; Michael R Wasielewski; J Fraser Stoddart
Journal:  Acc Chem Res       Date:  2016-02-02       Impact factor: 22.384

9.  Water-soluble pillar[7]arene: synthesis, pH-controlled complexation with paraquat, and application in constructing supramolecular vesicles.

Authors:  Zhengtao Li; Jie Yang; Guocan Yu; Jiuming He; Zeper Abliz; Feihe Huang
Journal:  Org Lett       Date:  2014-03-25       Impact factor: 6.005

10.  Monosulfonicpillar[5]arene: Synthesis, Characterization, and Complexation with Tetraphenylethene for Aggregation-Induced Emission.

Authors:  Xiao-Yu Jin; Nan Song; Xu Wang; Chun-Yu Wang; Yan Wang; Ying-Wei Yang
Journal:  Sci Rep       Date:  2018-03-05       Impact factor: 4.379
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  6 in total

1.  Thermodynamics of Pillararene•Guest Complexation: Blinded Dataset for the SAMPL9 Challenge.

Authors:  Chun-Lin Deng; Ming Cheng; Peter Y Zavalij; Lyle Isaacs
Journal:  New J Chem       Date:  2021-12-13       Impact factor: 3.591

Review 2.  Supramolecular hosts as in vivo sequestration agents for pharmaceuticals and toxins.

Authors:  Chun-Lin Deng; Steven L Murkli; Lyle D Isaacs
Journal:  Chem Soc Rev       Date:  2020-10-12       Impact factor: 54.564

Review 3.  Supramolecular Host-Guest Hydrogels for Corneal Regeneration.

Authors:  Amy C Madl; David Myung
Journal:  Gels       Date:  2021-10-05

Review 4.  When Molecules Meet in Water-Recent Contributions of Supramolecular Chemistry to the Understanding of Molecular Recognition Processes in Water.

Authors:  Stefan Kubik
Journal:  ChemistryOpen       Date:  2022-04       Impact factor: 2.630

5.  Flexible organic frameworks sequester neuromuscular blocking agents in vitro and reverse neuromuscular block in vivo.

Authors:  Yan Wu; Yue-Yang Liu; Hong-Kun Liu; Shang-Bo Yu; Furong Lin; Wei Zhou; Hui Wang; Dan-Wei Zhang; Zhan-Ting Li; Da Ma
Journal:  Chem Sci       Date:  2022-07-20       Impact factor: 9.969

6.  Ultrasensitive Electrochemical Sensor for Luteolin Based on Zirconium Metal-Organic Framework UiO-66/Reduced Graphene Oxide Composite Modified Glass Carbon Electrode.

Authors:  Qian Wang; Chunmeng Gu; Yafen Fu; Liangliang Liu; Yixi Xie
Journal:  Molecules       Date:  2020-10-05       Impact factor: 4.411
  6 in total

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