We report the synthesis, X-ray crystal structure, and molecular recognition properties of pillar[n]arene derivative P[6]AS, which we refer to as Pillar[6]MaxQ along with analogues P[5]AS and P[7]AS toward guests 1-18. The ultratight binding affinity of P[5]AS and P[6]AS toward quaternary (di)ammonium ions renders them prime candidates for in vitro and in vivo non-covalent bioconjugation, for imaging and delivery applications, and as in vivo sequestration agents.
We report the synthesis, X-ray crystal structure, and molecular recognition properties of pillar[n]class="Chemical">arene derivative class="Chemical">n class="Chemical">P[6]AS, which we refer to as Pillar[6]MaxQ along with analogues P[5]AS and P[7]AS toward guests 1-18. The ultratight binding affinity of P[5]AS and P[6]AS toward quaternary(di)ammonium ions renders them prime candidates for in vitro and in vivo non-covalent bioconjugation, for imaging and delivery applications, and as in vivo sequestration agents.
Authors: Jia-Rui Wu; Anthony U Mu; Bao Li; Chun-Yu Wang; Lei Fang; Ying-Wei Yang Journal: Angew Chem Int Ed Engl Date: 2018-07-03 Impact factor: 15.336
Authors: Edward J Dale; Nicolaas A Vermeulen; Michal Juríček; Jonathan C Barnes; Ryan M Young; Michael R Wasielewski; J Fraser Stoddart Journal: Acc Chem Res Date: 2016-02-02 Impact factor: 22.384