Literature DB >> 3241181

Structure and dynamics of serine hydrolase-organophosphate adducts.

I M Kovach1.   

Abstract

The structural profile for the interactions between serine proteases and organophosphorus (OP) compounds can be deduced from recent NMR and X-ray crystallographic data. Using the rationale proposed for serine proteases, dynamic data on the inhibition of acetylcholinesterase by OP compounds is also consistent with structural constraints and an impairment of the proton switch mechanism during phosphorylation.

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Year:  1988        PMID： 3241181     DOI： 10.3109/14756368809040726

Source DB:  PubMed          Journal:  J Enzyme Inhib        ISSN： 1026-5457


  10 in total

1.  Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase involved in insecticide resistance.

Authors:  S B Walsh; T A Dolden; G D Moores; M Kristensen; T Lewis; A L Devonshire; M S Williamson
Journal:  Biochem J       Date:  2001-10-01       Impact factor: 3.857

2.  Molecular dynamics study of active-site interactions with tetracoordinate transients in acetylcholinesterase and its mutants.

Authors:  I J Enyedy; I M Kovach; A Bencsura
Journal:  Biochem J       Date:  2001-02-01       Impact factor: 3.857

3.  Why does the G117H mutation considerably improve the activity of human butyrylcholinesterase against sarin? Insights from quantum mechanical/molecular mechanical free energy calculations.

Authors:  Yuan Yao; Junjun Liu; Chang-Guo Zhan
Journal:  Biochemistry       Date:  2012-10-23       Impact factor: 3.162

4.  Acetylcholinesterase inhibition by 1-methyl-4-phenylpyridinium ion, a bioactivated metabolite of MPTP.

Authors:  L Y Zang; H P Misra
Journal:  Mol Cell Biochem       Date:  1993-09-22       Impact factor: 3.396

5.  Inactivation of acetylcholinesterase by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride.

Authors:  Lun-Yi Zang; Hara P Misra
Journal:  Mol Cell Biochem       Date:  2003-12       Impact factor: 3.396

6.  Proton bridging in the interactions of thrombin with small inhibitors.

Authors:  Ildiko M Kovach; Paul Kelley; Carol Eddy; Frank Jordan; Ahmet Baykal
Journal:  Biochemistry       Date:  2009-08-04       Impact factor: 3.162

Review 7.  Proton Bridging in Catalysis by and Inhibition of Serine Proteases of the Blood Cascade System.

Authors:  Ildiko M Kovach
Journal:  Life (Basel)       Date:  2021-04-27

Review 8.  Arsenic binding to proteins.

Authors:  Shengwen Shen; Xing-Fang Li; William R Cullen; Michael Weinfeld; X Chris Le
Journal:  Chem Rev       Date:  2013-06-28       Impact factor: 60.622

9.  How is acetylcholinesterase phosphonylated by soman? An ab initio QM/MM molecular dynamics study.

Authors:  Gulseher Sarah Sirin; Yingkai Zhang
Journal:  J Phys Chem A       Date:  2014-05-09       Impact factor: 2.781

Review 10.  Human carboxylesterases: a comprehensive review.

Authors:  Dandan Wang; Liwei Zou; Qiang Jin; Jie Hou; Guangbo Ge; Ling Yang
Journal:  Acta Pharm Sin B       Date:  2018-06-25       Impact factor: 11.413
  10 in total

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