Mario J Trejo1, Melanie L Bell1, Haryana M Dhillon2, Janette L Vardy2,3,4. 1. Department Epidemiology and Biostatistics, Mel & Enid Zuckerman College of Public Health, The University of Arizona, Tucson, Arizona, USA. 2. Centre for Medical Psychology and Evidence-Based Decision-Making, University of Sydney, Sydney, Australia. 3. Concord Cancer Centre, Concord Repatriation General hospital, Concord, NSW, Australia. 4. Sydney Medical School, University of Sydney, Sydney, Australia.
Abstract
INTRODUCTION: Lung cancer patients presenting with advanced cancer face low survival rates and a high symptom burden. There have been mixed findings for the association between survival and various patient reported outcomes (PROs). METHODS: We used prospective data from 111 lung cancer patients with advanced stage III/IV disease to investigate the association of survival with PROs (European Organization for Research and Treatment of Cancer Core-30 and Lung Module). Cox proportional hazard models were used to examine the individual association between several PRO measures and survival. RESULTS: Pain in chest and global quality of life (QoL) were found to have the strongest association with survival with a 20% increased hazard of death per 10% increase in pain in chest and 14% decrease in hazard of death per 10% increase in global QoL. CONCLUSION: Our results provide more evidence for the value of PRO data to inform clinical and patient decision-making.
INTRODUCTION:Lung cancerpatients presenting with advanced cancer face low survival rates and a high symptom burden. There have been mixed findings for the association between survival and various patient reported outcomes (PROs). METHODS: We used prospective data from 111 lung cancerpatients with advanced stage III/IV disease to investigate the association of survival with PROs (European Organization for Research and Treatment of Cancer Core-30 and Lung Module). Cox proportional hazard models were used to examine the individual association between several PRO measures and survival. RESULTS:Pain in chest and global quality of life (QoL) were found to have the strongest association with survival with a 20% increased hazard of death per 10% increase in pain in chest and 14% decrease in hazard of death per 10% increase in global QoL. CONCLUSION: Our results provide more evidence for the value of PRO data to inform clinical and patient decision-making.
Entities:
Keywords:
Lung cancer; oncology; quality of life; survival; symptoms
Authors: Sarah Badaoui; Adel Shahnam; Michael J Sorich; Ashley M Hopkins; Ross A McKinnon; Ahmad Y Abuhelwa Journal: Transl Lung Cancer Res Date: 2022-03