Yosra Sr Elnaggar1,2, Bassma H Elwakil3, Salma S Elshewemi4, Moustafa Y El-Naggar4, Adnan A Bekhit1,5, Zakia A Olama4. 1. Faculty of Pharmacy, Alexandria University, Alexandria, Egypt. 2. Head of International-publication & Nanotechnology Consultation Center (INCC), Faculty of Pharmacy & Drug Manufacturing, Pharos University in Alexandria, Alexandria, Egypt. 3. Faculty of Allied Medical Science, Pharos University in Alexandria, Alexandria, Egypt. 4. Faculty of Science, Alexandria University, Alexandria, Egypt. 5. Pharmacy Program, Allied Health Department, College of Health & Sport sciences, University of Bahrain, P.O. Box 32038, Kingdom of Bahrain.
Abstract
Aim: The present study aimed to formulate novel cremophore-decorated chitosan nanoparticles of colistin, integrated with Siwa propolis extract, to solve bacterial resistance to colistin. Materials & methods: The novel nanoformula was prepared using an incorporation method. Physicochemical assessment and in vivo studies of the selected nanoformulations were performed. Results: The nanoformulation exhibited a nanosize of 48.3 nm, high ζ potential (43.6 mV), high entrapment efficiency (75%) and complete bacterial growth eradication within 2 h (minimum inhibitory concentration = 6.25 μg/ml). Histological examination showed that incorporation of colistin into the nanoformulation could successfully prevent its nephrotoxicity. Conclusion: Tailoring of proper nanocarrier could successfully revert bacteria from being colistin-resistant to colistin-sensitive. The developed nanoformulation can be considered as a potential antibacterial agent in pneumonia treatment.
Aim: The present study aimed to formulate novel cremophore-decorated chitosan nanoparticles of colistin, integrated with Siwa propolis extract, to solve bacterial resistance to colistin. Materials & methods: The novel nanoformula was prepared using an incorporation method. Physicochemical assessment and in vivo studies of the selected nanoformulations were performed. Results: The nanoformulation exhibited a nanosize of 48.3 nm, high ζ potential (43.6 mV), high entrapment efficiency (75%) and complete bacterial growth eradication within 2 h (minimum inhibitory concentration = 6.25 μg/ml). Histological examination showed that incorporation of colistin into the nanoformulation could successfully prevent its nephrotoxicity. Conclusion: Tailoring of proper nanocarrier could successfully revert bacteria from being colistin-resistant to colistin-sensitive. The developed nanoformulation can be considered as a potential antibacterial agent in pneumonia treatment.
Authors: Faizah S Aljohani; Moaaz T Hamed; Basant A Bakr; Yahya H Shahin; Marwa M Abu-Serie; Ashraf K Awaad; Hadir El-Kady; Bassma H Elwakil Journal: Sci Rep Date: 2022-04-15 Impact factor: 4.996
Authors: Aalaa A El-Attar; Hamdy B El-Wakil; Ahmed H Hassanin; Basant A Bakr; Tahani M Almutairi; Mohamed Hagar; Bassma H Elwakil; Zakia A Olama Journal: Membranes (Basel) Date: 2022-05-20
Authors: Esraa E Elshaer; Bassma H Elwakil; Areej Eskandrani; Salma S Elshewemi; Zakia A Olama Journal: Saudi J Biol Sci Date: 2021-10-22 Impact factor: 4.219
Authors: Faizah S Aljohani; Nadjet Rezki; Mohamed R Aouad; Mohamed Hagar; Basant A Bakr; Marwa M Shaaban; Bassma H Elwakil Journal: Antibiotics (Basel) Date: 2022-07-07
Authors: Shaimaa E Diab; Nourhan A Tayea; Bassma H Elwakil; Abir Abd El Mageid Gad; Doaa A Ghareeb; Zakia A Olama Journal: Int J Mol Sci Date: 2022-10-01 Impact factor: 6.208