Nina C B B Veiby1, Aida Simeunovic2,3,4, Martin Heier4,5, Cathrine Brunborg6, Naila Saddique1, Morten C Moe1,3, Knut Dahl-Jørgensen3,4,5, Hanna D Margeirsdottir4,5, Goran Petrovski1,3. 1. Center for Eye Research, Department of Ophthalmology, Oslo University Hospital, Oslo, Norway. 2. Department of Paediatrics and adolescent Medicine, Akershus University Hospital, Lorenskog, Norway. 3. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. 4. Oslo Diabetes Research Centre, Oslo, Norway. 5. Department of Paediatrics, Oslo University Hospital, Oslo, Norway. 6. Oslo Centre of Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway.
Abstract
PURPOSE: To clarify how early in the development of diabetic retinopathy (DR) can oxygen (O2 ) saturation changes be detected. METHODS: Retinal oximetry was performed in a cross-sectional study, involving 14- to 30-year-old individuals: 185 with type 1 diabetes (T1D) and 94 controls. The subjects were divided into four groups according to the grade of DR. One-way ANOVA and post hoc tests were used to test for differences in the mean O2 saturations between the groups. RESULTS: Fifty-eight (31 %) of the T1D patients had nonproliferative DR. There was no significant difference in O2 saturations between controls and T1D patients with no DR. Arteriolar and venular O2 saturations in T1D patients were significantly higher in moderate/severe DR than in no DR (p = 0.009 and p > 0.001), while venular O2 saturation was significantly higher in mild DR than in no DR (p = 0.013). CONCLUSION: Increase in venular O2 saturation could not be detected before mild retinopathy had developed, and the retinal O2 saturation increase was measurable on the venular side first. Our results suggest that the increase in O2 saturation is likely a consequence of DR.
PURPOSE: To clarify how early in the development of diabetic retinopathy (DR) can oxygen (O2 ) saturation changes be detected. METHODS: Retinal oximetry was performed in a cross-sectional study, involving 14- to 30-year-old individuals: 185 with type 1 diabetes (T1D) and 94 controls. The subjects were divided into four groups according to the grade of DR. One-way ANOVA and post hoc tests were used to test for differences in the mean O2 saturations between the groups. RESULTS: Fifty-eight (31 %) of the T1D patients had nonproliferative DR. There was no significant difference in O2 saturations between controls and T1D patients with no DR. Arteriolar and venular O2 saturations in T1D patients were significantly higher in moderate/severe DR than in no DR (p = 0.009 and p > 0.001), while venular O2 saturation was significantly higher in mild DR than in no DR (p = 0.013). CONCLUSION: Increase in venular O2 saturation could not be detected before mild retinopathy had developed, and the retinal O2 saturation increase was measurable on the venular side first. Our results suggest that the increase in O2 saturation is likely a consequence of DR.
Authors: Dragana Drobnjak Nes; Pål Berg-Hansen; Sigrid A de Rodez Benavent; Einar A Høgestøl; Mona K Beyer; Daniel A Rinker; Nina Veiby; Mia Karabeg; Beáta Éva Petrovski; Elisabeth G Celius; Hanne F Harbo; Goran Petrovski Journal: J Clin Med Date: 2022-05-31 Impact factor: 4.964
Authors: Nina C B B Veiby; Aida Simeunovic; Martin Heier; Cathrine Brunborg; Naila Saddique; Morten C Moe; Knut Dahl-Jørgensen; Hanna D Margeirsdottir; Goran Petrovski Journal: J Diabetes Res Date: 2020-11-30 Impact factor: 4.011