Stéphane Collaud1,2, Theresa Stork1,2, Hans-Ulrich Schildhaus3,2, Christoph Pöttgen4,2, Till Plönes1,2, Daniel Valdivia1,2, Mohamed Zaatar1,2, Uta Dirksen5,2, Sebastian Bauer6,2, Clemens Aigner1,2. 1. Department of Thoracic Surgery, University of Duisburg-Essen, Ruhrlandklinik, Essen, Germany. 2. German Cancer Consortium (DKTK), Center Essen, Germany. 3. Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. 4. Department of Radiation Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. 5. Department of Pediatrics III, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. 6. Department of Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Abstract
BACKGROUND AND OBJECTIVES: Primary pulmonary sarcoma (PPS) accounts for less than 1.1% of all pulmonary tumors. Few outcome data are reported. We evaluated outcome and prognostic factors in our series. METHODS: We retrospectively reviewed all patients who underwent resection for PPS in our center from 2002 to 2018. Survival was calculated from the date of surgery until last follow-up. Impact on survival of gender, type of lung resection, completeness of resection, grade, size, and TNM staging for lung cancer and soft tissue sarcoma (STS) was assessed. RESULTS: Thirteen patients were included. Eight (61.5%) patients received neoadjuvant treatment. Median tumor size at diagnosis was 11.5 cm (1-30 cm). Type of lung resection was wedge (n = 2, 15%), lobectomy (n = 4, 31%), intrapericardial (n = 3, 23%), and extrapleural pneumonectomies (n = 4, 31%). In-hospital mortality was 8%. Overall 5-year survival was 60%. Median disease-free survival was 17 months. Tumor size was a predictor for survival (P = .02) and recurrence (P = .05). Gender (P = .04) and type of lung resection (P = .04) were predictors of survival. T stage for STS of trunk and extremity, and TNM stage for lung cancer were predictors for recurrence (P = .03 and P = .04, respectively). CONCLUSION: Surgical resection within a multimodality therapy concept in highly selected patients can offer good long-term outcome.
BACKGROUND AND OBJECTIVES:Primary pulmonary sarcoma (PPS) accounts for less than 1.1% of all pulmonary tumors. Few outcome data are reported. We evaluated outcome and prognostic factors in our series. METHODS: We retrospectively reviewed all patients who underwent resection for PPS in our center from 2002 to 2018. Survival was calculated from the date of surgery until last follow-up. Impact on survival of gender, type of lung resection, completeness of resection, grade, size, and TNM staging for lung cancer and soft tissue sarcoma (STS) was assessed. RESULTS: Thirteen patients were included. Eight (61.5%) patients received neoadjuvant treatment. Median tumor size at diagnosis was 11.5 cm (1-30 cm). Type of lung resection was wedge (n = 2, 15%), lobectomy (n = 4, 31%), intrapericardial (n = 3, 23%), and extrapleural pneumonectomies (n = 4, 31%). In-hospital mortality was 8%. Overall 5-year survival was 60%. Median disease-free survival was 17 months. Tumor size was a predictor for survival (P = .02) and recurrence (P = .05). Gender (P = .04) and type of lung resection (P = .04) were predictors of survival. T stage for STS of trunk and extremity, and TNM stage for lung cancer were predictors for recurrence (P = .03 and P = .04, respectively). CONCLUSION: Surgical resection within a multimodality therapy concept in highly selected patients can offer good long-term outcome.
Authors: Caroline Rodrigues; Hagit Peretz Soroka; Agostino Pierro; Reto M Baertschiger; Marcelo Cypel; Laura Donahoe; Derek S Tsang; John Cho; Marc De Perrot; Thomas K Waddell; Abha A Gupta Journal: Curr Oncol Date: 2022-06-15 Impact factor: 3.109