Marek Sala1, Vladimír Kincl2,3, Milan Kamínek4,5, Jiří Vašina4,6, Jan Máchal4,7, Roman Panovský1,4, Věra Feitová4,8, Lukáš Opatřil1,4, Tomáš Holeček4,8. 1. Department of Internal Medicine/Cardiology, St. Anne´s University Hospital, Masaryk University, Pekařská 53, 656 91, Brno, Czech Republic. 2. Department of Internal Medicine/Cardiology, St. Anne´s University Hospital, Masaryk University, Pekařská 53, 656 91, Brno, Czech Republic. vladimir.kincl@fnusa.cz. 3. International Clinical Research Center, St. Anne´s University Hospital, Brno, Czech Republic. vladimir.kincl@fnusa.cz. 4. International Clinical Research Center, St. Anne´s University Hospital, Brno, Czech Republic. 5. Department of Nuclear Medicine, University Hospital Olomouc, Palacký University, Olomouc, Czech Republic. 6. Department of Nuclear Medicine, Masaryk Memorial Cancer Center, Brno, Czech Republic. 7. Department of Pathological Physiology, Masaryk University, Brno, Czech Republic. 8. Department of Medical Imaging, St. Anne´s University Hospital, Masaryk University, Brno, Czech Republic.
Abstract
BACKGROUND: Cadmium-Zinc-Telluride (CZT) technology allows use of low activities of radiopharmaceuticals. The aim was to verify the values of left ventricular volume parameters, obtained via ultra-low-dose thallium Single Photon Emission Computed Tomography (SPECT) using a CZT camera. METHODS AND RESULTS: Forty-five patients referred for an assessment of myocardial perfusion or viability imaging were examined using CZT-SPECT and 1.5 T magnetic resonance (MRI) scanner. The ultra-low-dose protocol with 0.5 Mbq 201-Tl per kg of body weight was used. The values of end-systolic (ESV) and end-diastolic volumes (EDV), left ventricular ejection fraction (EF) and myocardial mass (MM) were assessed using both techniques. A very good correlation was found between the EF, ESV, and EDV values assessed with CZT-SPECT and cardiac magnetic resonance MRI; the Pearson coefficients were 0.86, 0.95, and 0.91, respectively. A moderate correlation was found for myocardial mass, r = 0.57. Compared to MRI, SPECT systematically overestimated ESV and MM, while it underestimates the EF, with P ≤ .001 in all cases. There was no difference in EDV estimation. CONCLUSIONS: Left ventricular volumes and ejection fraction assessed via ultra-low-dose CZT-SPECT showed very good correlation with the values obtained by MRI. A moderate correlation was found for myocardial mass.
BACKGROUND: Cadmium-Zinc-Telluride (CZT) technology allows use of low activities of radiopharmaceuticals. The aim was to verify the values of left ventricular volume parameters, obtained via ultra-low-dose thallium Single Photon Emission Computed Tomography (SPECT) using a CZT camera. METHODS AND RESULTS: Forty-five patients referred for an assessment of myocardial perfusion or viability imaging were examined using CZT-SPECT and 1.5 T magnetic resonance (MRI) scanner. The ultra-low-dose protocol with 0.5 Mbq 201-Tl per kg of body weight was used. The values of end-systolic (ESV) and end-diastolic volumes (EDV), left ventricular ejection fraction (EF) and myocardial mass (MM) were assessed using both techniques. A very good correlation was found between the EF, ESV, and EDV values assessed with CZT-SPECT and cardiac magnetic resonance MRI; the Pearson coefficients were 0.86, 0.95, and 0.91, respectively. A moderate correlation was found for myocardial mass, r = 0.57. Compared to MRI, SPECT systematically overestimated ESV and MM, while it underestimates the EF, with P ≤ .001 in all cases. There was no difference in EDV estimation. CONCLUSIONS: Left ventricular volumes and ejection fraction assessed via ultra-low-dose CZT-SPECT showed very good correlation with the values obtained by MRI. A moderate correlation was found for myocardial mass.
Authors: Roman Panovský; Júlia Borová; Martin Pleva; Věra Feitová; Petr Novotný; Vladimír Kincl; Tomáš Holeček; Jaroslav Meluzín; Ondřej Sochor; Radka Štěpánová Journal: BMC Cardiovasc Disord Date: 2017-06-28 Impact factor: 2.298
Authors: Jeanette Schulz-Menger; David A Bluemke; Jens Bremerich; Scott D Flamm; Mark A Fogel; Matthias G Friedrich; Raymond J Kim; Florian von Knobelsdorff-Brenkenhoff; Christopher M Kramer; Dudley J Pennell; Sven Plein; Eike Nagel Journal: J Cardiovasc Magn Reson Date: 2013-05-01 Impact factor: 5.364