Literature DB >> 32410023

Analysis of Drosophila melanogaster Lifespan.

Gary N Landis1, Devon Doherty1, John Tower2.   

Abstract

The laboratory fruit fly Drosophila melanogaster is one of the leading models for the study of aging. Whereas several behavioral and physiological biomarkers of aging have been identified for Drosophila, lifespan remains the most robust measure of aging rate. Aging and lifespan can be modulated by genetic alterations, as well as by drugs and dietary components, to reveal basic and conserved mechanisms of aging. Here methods are presented for Drosophila lifespan assay, including media preparation, supplementation of media with various drugs, culturing of the flies, passaging flies and recording deaths, and the analysis of lifespan data.

Entities:  

Keywords:  Aging; Drosophila; Drosophila media; Gompertz; Lifespan; Mortality rate

Mesh：

Substances：

Year:  2020        PMID： 32410023      PMCID： PMC8016145          DOI： 10.1007/978-1-0716-0592-9_4

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  13 in total

1.  Predicting death in female Drosophila.

Authors:  Laurence D Mueller; Parvin Shahrestani; Casandra L Rauser
Journal:  Exp Gerontol       Date:  2009-09-30       Impact factor: 4.032

2.  Age-specific and lifetime behavior patterns in Drosophila melanogaster and the Mediterranean fruit fly, Ceratitis capitata.

Authors:  James R Carey; Nikos Papadopoulos; Nikos Kouloussis; Byron Katsoyannos; Hans-Georg Müller; Jane-Ling Wang; Yi-Kuan Tseng
Journal:  Exp Gerontol       Date:  2005-11-16       Impact factor: 4.032

3.  Multiple Metazoan Life-span Interventions Exhibit a Sex-specific Strehler-Mildvan Inverse Relationship Between Initial Mortality Rate and Age-dependent Mortality Rate Acceleration.

Authors:  Jie Shen; Gary N Landis; John Tower
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2016-02-18       Impact factor: 6.053

4.  Conditional inhibition of autophagy genes in adult Drosophila impairs immunity without compromising longevity.

Authors:  Chunli Ren; Steven E Finkel; John Tower
Journal:  Exp Gerontol       Date:  2008-10-12       Impact factor: 4.032

5.  Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster.

Authors:  Gary N Landis; Diana Abdueva; Dmitriy Skvortsov; Junsheng Yang; Beth E Rabin; James Carrick; Simon Tavaré; John Tower
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-10       Impact factor: 11.205

6.  Expression of hsp22 and hsp70 transgenes is partially predictive of drosophila survival under normal and stress conditions.

Authors:  Junsheng Yang; John Tower
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2009-05-06       Impact factor: 6.053

7.  Increased internal and external bacterial load during Drosophila aging without life-span trade-off.

Authors:  Chunli Ren; Paul Webster; Steven E Finkel; John Tower
Journal:  Cell Metab       Date:  2007-08       Impact factor: 27.287

8.  Distinct biological epochs in the reproductive life of female Drosophila melanogaster.

Authors:  Blanka Rogina; Tom Wolverton; Tyson G Bross; Kun Chen; Hans-Georg Müller; James R Carey
Journal:  Mech Ageing Dev       Date:  2007-06-20       Impact factor: 5.432

9.  Doxycycline-induced transgene expression during Drosophila development and aging.

Authors:  E T Bieschke; J C Wheeler; J Tower
Journal:  Mol Gen Genet       Date:  1998-06

10.  The progesterone antagonist mifepristone/RU486 blocks the negative effect on life span caused by mating in female Drosophila.

Authors:  Gary N Landis; Matthew P Salomon; Daniel Keroles; Nicholas Brookes; Troy Sekimura; John Tower
Journal:  Aging (Albany NY)       Date:  2015-01       Impact factor: 5.682
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  5 in total

1.  Metabolic Signatures of Life Span Regulated by Mating, Sex Peptide, and Mifepristone/RU486 in Female Drosophila melanogaster.

Authors:  Gary N Landis; Devon V Doherty; Chia-An Yen; Lu Wang; Yang Fan; Ina Wang; Jonah Vroegop; Tianyi Wang; Jimmy Wu; Palak Patel; Shinwoo Lee; Mina Abdelmesieh; Jie Shen; Daniel E L Promislow; Sean P Curran; John Tower
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2021-01-18       Impact factor: 6.053

2.  Lifespan and ROS levels in different Drosophila melanogaster strains after 24 h hypoxia exposure.

Authors:  Sandro Malacrida; Federica De Lazzari; Simona Mrakic-Sposta; Alessandra Vezzoli; Mauro A Zordan; Marco Bisaglia; Giulio Maria Menti; Nicola Meda; Giovanni Frighetto; Gerardo Bosco; Tomas Dal Cappello; Giacomo Strapazzon; Carlo Reggiani; Maristella Gussoni; Aram Megighian
Journal:  Biol Open       Date:  2022-06-29       Impact factor: 2.643

3.  Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinations of pro-longevity interventions.

Authors:  Mikhail V Shaposhnikov; Zulfiya G Guvatova; Nadezhda V Zemskaya; Liubov A Koval; Eugenia V Schegoleva; Anastasia A Gorbunova; Denis A Golubev; Natalya R Pakshina; Natalia S Ulyasheva; Ilya A Solovev; Margarita A Bobrovskikh; Nataly E Gruntenko; Petr N Menshanov; George S Krasnov; Anna V Kudryavseva; Alexey A Moskalev
Journal:  Commun Biol       Date:  2022-06-09

4.  Geroprotective potential of genetic and pharmacological interventions to endogenous hydrogen sulfide synthesis in Drosophila melanogaster.

Authors:  Mikhail V Shaposhnikov; Nadezhda V Zemskaya; Liubov A Koval; Eugenia V Schegoleva; Daria V Yakovleva; Natalia S Ulyasheva; Anastasia A Gorbunova; Natalya R Minnikhanova; Alexey A Moskalev
Journal:  Biogerontology       Date:  2021-02-05       Impact factor: 4.277

5.  Mifepristone Increases Life Span in Female Drosophila Without Detectable Antibacterial Activity.

Authors:  Gary N Landis; Luke Riggan; Hans S Bell; William Vu; Tianyi Wang; Ina Wang; Felicia I Tejawinata; Sebastian Ko; John Tower
Journal:  Front Aging       Date:  2022-07-22
  5 in total

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