Literature DB >> 3240998

Nonspecific lipid transfer protein (sterol carrier protein-2) is located in rat liver peroxisomes.

M Tsuneoka1, A Yamamoto, Y Fujiki, Y Tashiro.   

Abstract

Intracellular localization of nonspecific lipid transfer protein (nsLTP) in rat hepatocytes was investigated by immunoblot analysis of the subcellular fractions and immunoelectron microscopy, using affinity-purified antibody against nsLTP. Immunoblot analysis showed that the protein exists in the peroxisomal and cytosolic fractions. Further study indicated that nsLTP exists in the soluble subfraction of the peroxisomes. Immunoelectron microscopic observation revealed that nsLTP is highly concentrated in the matrices of the peroxisomes. From these results, we concluded that nsLTP mainly exists in the matrix of the peroxisomes. The role of nsLTP is discussed.

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Year:  1988        PMID： 3240998     DOI： 10.1093/oxfordjournals.jbchem.a122510

Source DB:  PubMed          Journal:  J Biochem        ISSN： 0021-924X            Impact factor:   3.387


  11 in total

1.  Molecular cloning and deduced amino acid sequence of nonspecific lipid transfer protein (sterol carrier protein 2) of rat liver: a higher molecular mass (60 kDa) protein contains the primary sequence of nonspecific lipid transfer protein as its C-terminal part.

Authors:  T Mori; T Tsukamoto; H Mori; Y Tashiro; Y Fujiki
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-15       Impact factor: 11.205

Review 2.  Intracellular sterol trafficking.

Authors:  M P Reinhart
Journal:  Experientia       Date:  1990-06-15

Review 3.  Phospholipid transfer proteins revisited.

Authors:  K W Wirtz
Journal:  Biochem J       Date:  1997-06-01       Impact factor: 3.857

4.  High-affinity binding of very-long-chain fatty acyl-CoA esters to the peroxisomal non-specific lipid-transfer protein (sterol carrier protein-2).

Authors:  T B Dansen; J Westerman; F S Wouters; R J Wanders; A van Hoek; T W Gadella; K W Wirtz
Journal:  Biochem J       Date:  1999-04-01       Impact factor: 3.857

Review 5.  Biochemistry of peroxisomes in health and disease.

Authors:  I Singh
Journal:  Mol Cell Biochem       Date:  1997-02       Impact factor: 3.396

6.  FRET microscopy demonstrates molecular association of non-specific lipid transfer protein (nsL-TP) with fatty acid oxidation enzymes in peroxisomes.

Authors:  F S Wouters; P I Bastiaens; K W Wirtz; T M Jovin
Journal:  EMBO J       Date:  1998-12-15       Impact factor: 11.598

Review 7.  Organelle biogenesis and intracellular lipid transport in eukaryotes.

Authors:  D R Voelker
Journal:  Microbiol Rev       Date:  1991-12

8.  Phospholipid-transfer proteins and their mRNAs in developing rat lung and in alveolar type-II cells.

Authors:  J J Batenburg; B C Ossendorp; G T Snoek; K W Wirtz; M Houweling; R H Elfring
Journal:  Biochem J       Date:  1994-02-15       Impact factor: 3.857

9.  Regulation of sterol carrier protein 2 (SCP2) gene expression in rat peritoneal macrophages during foam cell formation. A key role for free cholesterol content.

Authors:  A Hirai; T Kino; K Tokinaga; K Tahara; Y Tamura; S Yoshida
Journal:  J Clin Invest       Date:  1994-12       Impact factor: 14.808

10.  The presence and subcellular distribution of sterol carrier protein 2 in embryonic-chick tissues.

Authors:  M P Reinhart; S J Avart; T O Dobson; T A Foglia
Journal:  Biochem J       Date:  1993-11-01       Impact factor: 3.857
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