Qingxian Cai1, Fengjuan Chen2, Tao Wang3, Fang Luo1, Xiaohui Liu1, Qikai Wu1, Qing He1, Zhaoqin Wang1, Yingxia Liu1, Lei Liu1, Jun Chen4, Lin Xu5. 1. National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China. 2. Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China. 3. School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China. 4. National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China drchenjun@163.com xulin27@mail.sysu.edu.cn. 5. School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China drchenjun@163.com xulin27@mail.sysu.edu.cn.
Abstract
OBJECTIVE: Patients with obesity are at increased risk of exacerbations from viral respiratory infections. However, the association of obesity with the severity of coronavirus disease 2019 (COVID-19) is unclear. We examined this association using data from the only referral hospital in Shenzhen, China. RESEARCH DESIGN AND METHODS: A total of 383 consecutively hospitalized patients with COVID-19 admitted from 11 January 2020 to 16 February 2020 and followed until 26 March 2020 at the Third People's Hospital of Shenzhen were included. Underweight was defined as a BMI <18.5 kg/m2, normal weight as 18.5-23.9 kg/m2, overweight as 24.0-27.9 kg/m2, and obesity as ≥28 kg/m2. RESULTS: Of the 383 patients, 53.1% were normal weight, 4.2% were underweight, 32.0% were overweight, and 10.7% were obese at admission. Obese patients tended to have symptoms of cough (P = 0.03) and fever (P = 0.06) compared with patients who were not obese. Compared with normal weight patients, those who were overweight had 1.84-fold odds of developing severe COVID-19 (odds ratio [OR] 1.84, 95% CI 0.99-3.43, P = 0.05), while those who were obese were at 3.40-fold odds of developing severe disease (OR 3.40, 95% CI 1.40-2.86, P = 0.007), after adjusting for age, sex, epidemiological characteristics, days from disease onset to hospitalization, presence of hypertension, diabetes, cardiovascular disease, chronic obstructive pulmonary disease, liver disease, and cancer, and drug used for treatment. Additionally, after similar adjustment, men who were obese versus those who were normal weight were at increased odds of developing severe COVID-19 (OR 5.66, 95% CI 1.80-17.75, P = 0.003). CONCLUSIONS: In this study, obese patients had increased odds of progressing to severe COVID-19. As the severe acute respiratory syndrome coronavirus 2 may continue to spread worldwide, clinicians should pay close attention to obese patients, who should be carefully managed with prompt and aggressive treatment.
OBJECTIVE:Patients with obesity are at increased risk of exacerbations from viral respiratory infections. However, the association of obesity with the severity of coronavirus disease 2019 (COVID-19) is unclear. We examined this association using data from the only referral hospital in Shenzhen, China. RESEARCH DESIGN AND METHODS: A total of 383 consecutively hospitalized patients with COVID-19 admitted from 11 January 2020 to 16 February 2020 and followed until 26 March 2020 at the Third People's Hospital of Shenzhen were included. Underweight was defined as a BMI <18.5 kg/m2, normal weight as 18.5-23.9 kg/m2, overweight as 24.0-27.9 kg/m2, and obesity as ≥28 kg/m2. RESULTS: Of the 383 patients, 53.1% were normal weight, 4.2% were underweight, 32.0% were overweight, and 10.7% were obese at admission. Obesepatients tended to have symptoms of cough (P = 0.03) and fever (P = 0.06) compared with patients who were not obese. Compared with normal weight patients, those who were overweight had 1.84-fold odds of developing severe COVID-19 (odds ratio [OR] 1.84, 95% CI 0.99-3.43, P = 0.05), while those who were obese were at 3.40-fold odds of developing severe disease (OR 3.40, 95% CI 1.40-2.86, P = 0.007), after adjusting for age, sex, epidemiological characteristics, days from disease onset to hospitalization, presence of hypertension, diabetes, cardiovascular disease, chronic obstructive pulmonary disease, liver disease, and cancer, and drug used for treatment. Additionally, after similar adjustment, men who were obese versus those who were normal weight were at increased odds of developing severe COVID-19 (OR 5.66, 95% CI 1.80-17.75, P = 0.003). CONCLUSIONS: In this study, obesepatients had increased odds of progressing to severe COVID-19. As the severe acute respiratory syndrome coronavirus 2 may continue to spread worldwide, clinicians should pay close attention to obesepatients, who should be carefully managed with prompt and aggressive treatment.
Authors: Hamid Bolouri; Cate Speake; David Skibinski; S Alice Long; Anne M Hocking; Daniel J Campbell; Jessica A Hamerman; Uma Malhotra; Jane H Buckner Journal: J Clin Invest Date: 2021-02-01 Impact factor: 14.808
Authors: Waqas Ullah; Sohaib Roomi; Nayab Nadeem; Rehan Saeed; Shafaq Tariq; Moataz Ellithi; Shujaul Haq; Ahmad Arslan; John Madara; Margot Boigon; Donald C Haas; David L Fischman Journal: J Clin Med Res Date: 2021-04-27
Authors: Moza Mohamed Alzaabi; Rania Hamdy; Naglaa S Ashmawy; Alshaimaa M Hamoda; Fatemah Alkhayat; Neda Naser Khademi; Sara Mahmoud Abo Al Joud; Ali A El-Keblawy; Sameh S M Soliman Journal: Phytochem Rev Date: 2021-05-22 Impact factor: 7.741