Chirag Shah1, Zoubir Ouhib2, Mitchell Kamrava3, Shlomo A Koyfman4, Shauna R Campbell4, Ajay Bhatnagar5, Joycelin Canavan4, Zain Husain6, Christopher A Barker7, Gil'ad N Cohen8, John Strasswimmer9, Nikhil Joshi4. 1. Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH. Electronic address: csshah27@hotmail.com. 2. Lynn Cancer Institute, Boca Raton Regional Hospital, Boca Raton, FL. 3. Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA. 4. Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH. 5. Department of Radiation Oncology, Alliance Oncology, Casa Grande, AZ. 6. Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. 7. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY. 8. Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY. 9. College of Medicine (Dermatology) and College of Sciences (Biochemistry), Florida Atlantic University, Boca Raton, FL.
Abstract
PURPOSE: Keratinocyte carcinoma (KC, previously nonmelanoma skin cancer) represents the most common cancer worldwide. While surgical treatment is commonly utilized, various radiation therapy techniques are available including external beam and brachytherapy. As such, the American Brachytherapy Society has created an updated consensus statement regarding the use of brachytherapy in the treatment of KCs. METHODS: Physicians and physicists with expertise in skin cancer and brachytherapy created a consensus statement for appropriate patient selection, data, dosimetry, and utilization of skin brachytherapy and techniques based on a literature search and clinical experience. RESULTS: Guidelines for patient selection, evaluation, and dose/fractionation schedules to optimize outcomes for patients with KC undergoing brachytherapy are presented. Studies of electronic brachytherapy are emerging, although limited long-term data or comparative data are available. Radionuclide-based brachytherapy represents an appropriate option for patients with small KCs with multiple techniques available. CONCLUSIONS: Skin brachytherapy represents a standard of care option for appropriately selected patients with KC. Radionuclide-based brachytherapy represents a well-established technique; however, the current recommendation is that electronic brachytherapy be used for KC on prospective clinical trial or registry because of a paucity of mature data.
PURPOSE: Keratinocyte carcinoma (KC, previously nonmelanoma skin cancer) represents the most common cancer worldwide. While surgical treatment is commonly utilized, various radiation therapy techniques are available including external beam and brachytherapy. As such, the American Brachytherapy Society has created an updated consensus statement regarding the use of brachytherapy in the treatment of KCs. METHODS: Physicians and physicists with expertise in skin cancer and brachytherapy created a consensus statement for appropriate patient selection, data, dosimetry, and utilization of skin brachytherapy and techniques based on a literature search and clinical experience. RESULTS: Guidelines for patient selection, evaluation, and dose/fractionation schedules to optimize outcomes for patients with KC undergoing brachytherapy are presented. Studies of electronic brachytherapy are emerging, although limited long-term data or comparative data are available. Radionuclide-based brachytherapy represents an appropriate option for patients with small KCs with multiple techniques available. CONCLUSIONS: Skin brachytherapy represents a standard of care option for appropriately selected patients with KC. Radionuclide-based brachytherapy represents a well-established technique; however, the current recommendation is that electronic brachytherapy be used for KC on prospective clinical trial or registry because of a paucity of mature data.
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Authors: Grzegorz Bielęda; Adam Chicheł; Marek Boehlke; Grzegorz Zwierzchowski; Artur Chyrek; Wojciech Burchardt; Patrycja Stefaniak; Natalia Wiśniewska; Kinga Czereba; Julian Malicki Journal: J Contemp Brachytherapy Date: 2022-03-25