Literature DB >> 32409109

Minicircle DNA: The Future for DNA-Based Vectors?

Ana Margarida Almeida1, João António Queiroz1, Fani Sousa1, Ângela Sousa2.   

Abstract

Minicircle DNA (mcDNA) is a smaller and safer version of non-viral DNA vectors that results from a cutting-edge in vivo recombination process to excise prokaryotic sequences from plasmid DNA (pDNA). Considering the molecule's potential and increasing interest as a non-viral DNA-based therapeutic, biomanufacturing methodologies need to be improved, especially in downstream processing.
Copyright © 2020 Elsevier Ltd. All rights reserved.

Keywords:  downstream processing; gene delivery; minicircle DNA biomanufacturing; plasmid DNA; upstream processing

Mesh：

Substances：

Year:  2020        PMID： 32409109     DOI： 10.1016/j.tibtech.2020.04.008

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN： 0167-7799            Impact factor:   19.536


  8 in total

Review 1.  Synthetic biomarkers: a twenty-first century path to early cancer detection.

Authors:  Gabriel A Kwong; Sharmistha Ghosh; Lena Gamboa; Christos Patriotis; Sudhir Srivastava; Sangeeta N Bhatia
Journal:  Nat Rev Cancer       Date:  2021-09-06       Impact factor: 60.716

2.  Maximization of the Minicircle DNA Vaccine Production Expressing SARS-CoV-2 RBD.

Authors:  Cathy Ventura; Dalinda Eusébio; Ana M Gonçalves; Jorge Barroca-Ferreira; Diana Costa; Zhengrong Cui; Luís A Passarinha; Ângela Sousa
Journal:  Biomedicines       Date:  2022-04-25

3.  Toward QbD Process Understanding on DNA Vaccine Purification Using Design of Experiment.

Authors:  Lalintip Hocharoen; Sarawuth Noppiboon; Panit Kitsubun
Journal:  Front Bioeng Biotechnol       Date:  2021-05-12

4.  Improving therapeutic potential of non-viral minimized DNA vectors.

Authors:  Lirio M Arévalo-Soliz; Cinnamon L Hardee; Jonathan M Fogg; Nathan R Corman; Cameron Noorbakhsh; Lynn Zechiedrich
Journal:  Cell Gene Ther Insights       Date:  2020-11-19

5.  Development of Minicircle Vectors Encoding COL7A1 Gene with Human Promoters for Non-Viral Gene Therapy for Recessive Dystrophic Epidermolysis Bullosa.

Authors:  Xianqing Wang; Fatma Alshehri; Darío Manzanares; Yinghao Li; Zhonglei He; Bei Qiu; Ming Zeng; Sigen A; Irene Lara-Sáez; Wenxin Wang
Journal:  Int J Mol Sci       Date:  2021-11-26       Impact factor: 5.923

Review 6.  Gene therapy to enhance angiogenesis in chronic wounds.

Authors:  Elnaz Shaabani; Maryam Sharifiaghdam; Reza Faridi-Majidi; Stefaan C De Smedt; Kevin Braeckmans; Juan C Fraire
Journal:  Mol Ther Nucleic Acids       Date:  2022-08-17       Impact factor: 10.183

7.  Synthesis and Characterization of Mannosylated Formulations to Deliver a Minicircle DNA Vaccine.

Authors:  Ana Sofia Serra; Dalinda Eusébio; Ana Raquel Neves; Tânia Albuquerque; Himanshu Bhatt; Swati Biswas; Diana Costa; Ângela Sousa
Journal:  Pharmaceutics       Date:  2021-05-07       Impact factor: 6.321

8.  Cancer Detection Using an Artificial Secretable MicroRNA Found in Blood and Urine.

Authors:  Pei-Wei Shueng; Kuang-Chung Shih; Sanjiv Sam Gambhir; Deng-Yu Kuo; Hui-Yen Chuang
Journal:  Biomedicines       Date:  2022-03-07
  8 in total

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