Chidinma P Anakwenze1, Susan McGovern2, Nicolette Taku2, Kaiping Liao3, David R Boyce-Fappiano2, Carlos Kamiya-Matsuoka4, Amol Ghia2, Caroline Chung2, Daniel Trifiletti5, Sherise D Ferguson6, Jing Li2, Debra Nana Yeboa7. 1. Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address: cpanakwenze@mdanderson.org. 2. Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 3. Department of Health Services Research, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 4. Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 5. Department of Radiation Oncology, Mayo Clinic, Jacksonville, Florida, USA. 6. Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 7. Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Health Services Research, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Abstract
BACKGROUND: The role of adjuvant radiation after gross total resection (GTR) for grade II meningioma is evolving, prompting further evaluation in NRG-BN003, a phase 3 national trial. Furthermore, the relationship between facility volume and outcomes in patients with grade II meningioma after GTR has not been examined at a national level. We aim to assess overall survival (OS) of patients with grade II meningioma after GTR by surgical case volume and OS by receipt of adjuvant radiation. METHODS: We used the National Cancer Database to identity 2823 patients diagnosed with grade II meningioma who underwent GTR. Propensity score matching was applied to balance covariates in patients with grade II meningioma after GTR stratified by adjuvant radiation status. Multivariable logistic regression was used to assess factors associated with radiation receipt. Kaplan-Meier and log-rank tests were used to assess OS by facility volume. RESULTS: As facility volume increased, OS increased, with a 5-year OS of 72.8% for facilities with GTR grade II meningioma volumes of ≤8 cases per decade and 87.5% for >8 cases per decade (P < 0.0001). There was no difference in 5-year OS between GTR alone and GTR with adjuvant radiation (84.8% vs. 86.4%; P = 0.151). Covariates significantly associated with radiation receipt included facility location, facility volume, distance, and tumor size. CONCLUSIONS: Treatment at higher surgical case volume facilities is associated with improved OS for GTR grade II meningioma. These facilities also have more patients receiving adjuvant radiation. However, we observed no difference in OS between adjuvant radiation and surgery alone.
BACKGROUND: The role of adjuvant radiation after gross total resection (GTR) for grade II meningioma is evolving, prompting further evaluation in NRG-BN003, a phase 3 national trial. Furthermore, the relationship between facility volume and outcomes in patients with grade II meningioma after GTR has not been examined at a national level. We aim to assess overall survival (OS) of patients with grade II meningioma after GTR by surgical case volume and OS by receipt of adjuvant radiation. METHODS: We used the National Cancer Database to identity 2823 patients diagnosed with grade II meningioma who underwent GTR. Propensity score matching was applied to balance covariates in patients with grade II meningioma after GTR stratified by adjuvant radiation status. Multivariable logistic regression was used to assess factors associated with radiation receipt. Kaplan-Meier and log-rank tests were used to assess OS by facility volume. RESULTS: As facility volume increased, OS increased, with a 5-year OS of 72.8% for facilities with GTR grade II meningioma volumes of ≤8 cases per decade and 87.5% for >8 cases per decade (P < 0.0001). There was no difference in 5-year OS between GTR alone and GTR with adjuvant radiation (84.8% vs. 86.4%; P = 0.151). Covariates significantly associated with radiation receipt included facility location, facility volume, distance, and tumor size. CONCLUSIONS: Treatment at higher surgical case volume facilities is associated with improved OS for GTR grade II meningioma. These facilities also have more patients receiving adjuvant radiation. However, we observed no difference in OS between adjuvant radiation and surgery alone.
Authors: Khodayar Goshtasbi; Arash Abiri; Brandon M Lehrich; Yarah M Haidar; Tjoson Tjoa; Edward C Kuan Journal: Head Neck Date: 2021-05-17 Impact factor: 3.821
Authors: Ciro Mastantuoni; Luigi Maria Cavallo; Felice Esposito; Elena d'Avella; Oreste de Divitiis; Teresa Somma; Andrea Bocchino; Gianluca Lorenzo Fabozzi; Paolo Cappabianca; Domenico Solari Journal: Cancers (Basel) Date: 2022-06-10 Impact factor: 6.575