Y Yu1, L Hu1, X Huang1, W Zhou2, H Bao3,4, X Cheng5,6. 1. Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, Jiangxi, China. 2. Center for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. 3. Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, Jiangxi, China. huihui_bao77@126.com. 4. Center for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. huihui_bao77@126.com. 5. Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, Jiangxi, China. xiaoshumenfan126@163.com. 6. Center for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. xiaoshumenfan126@163.com.
Abstract
PURPOSE: Both high-density lipoprotein cholesterol (HDL-C) and body mass index (BMI) have an impact on the prevalence of stroke. However, it is unclear whether BMI can modify the relationship between HDL-C and stroke. Therefore, we aimed to assess the effect of the BMI on the association between HDL-C and stroke in a hypertensive population without atrial fibrillation (AF). METHODS: We analyzed data of 10,925 hypertensive patients without AF from the Chinese Hypertension Registry Study. BMI was categorized as < 24 and ≥ 24 kg/m2. Multivariate logistic regression and smooth curve fitting (penalized spline method) were used to analyze the association between HDL-C and stroke in different BMI groups. Subgroup analysis and interaction tests were used to explore the effect of other variables on this relationship. RESULTS: The results showed a negative association between HDL-C and stroke in the BMI < 24 kg/m2 group, but HDL-C was not associated with stroke in the BMI ≥ 24 kg/m2 group. In the BMI < 24 kg/m2 group, each 1 mmol/L increase in HDL-C was associated with a 50% decreased risk of stroke [odds ratio (OR) 0.50, 95% confidence interval (CI) 0.38-0.66]. No significant relationship between HDL-C and stroke was observed in the BMI ≥ 24 kg/m2 group (OR 0.73, 95% CI 0.49-1.10). There was a significant interaction between BMI and HDL-C in regard to the prevalence of stroke in the hypertensive population without AF (PInteraction = 0.027). CONCLUSIONS: We found an inverse association between HDL-C and stroke only in the BMI < 24 kg/m2 group. The finding suggested that BMI could modify the association between HDL-C and stroke in hypertensive populations without AF.
PURPOSE: Both high-density lipoprotein cholesterol (HDL-C) and body mass index (BMI) have an impact on the prevalence of stroke. However, it is unclear whether BMI can modify the relationship between HDL-C and stroke. Therefore, we aimed to assess the effect of the BMI on the association between HDL-C and stroke in a hypertensive population without atrial fibrillation (AF). METHODS: We analyzed data of 10,925 hypertensivepatients without AF from the Chinese Hypertension Registry Study. BMI was categorized as < 24 and ≥ 24 kg/m2. Multivariate logistic regression and smooth curve fitting (penalized spline method) were used to analyze the association between HDL-C and stroke in different BMI groups. Subgroup analysis and interaction tests were used to explore the effect of other variables on this relationship. RESULTS: The results showed a negative association between HDL-C and stroke in the BMI < 24 kg/m2 group, but HDL-C was not associated with stroke in the BMI ≥ 24 kg/m2 group. In the BMI < 24 kg/m2 group, each 1 mmol/L increase in HDL-C was associated with a 50% decreased risk of stroke [odds ratio (OR) 0.50, 95% confidence interval (CI) 0.38-0.66]. No significant relationship between HDL-C and stroke was observed in the BMI ≥ 24 kg/m2 group (OR 0.73, 95% CI 0.49-1.10). There was a significant interaction between BMI and HDL-C in regard to the prevalence of stroke in the hypertensive population without AF (PInteraction = 0.027). CONCLUSIONS: We found an inverse association between HDL-C and stroke only in the BMI < 24 kg/m2 group. The finding suggested that BMI could modify the association between HDL-C and stroke in hypertensive populations without AF.
Entities:
Keywords:
Atrial fibrillation; Body mass index; High-density lipoprotein cholesterol; Hypertension; Stroke
Authors: Yurong Zhang; Jaakko Tuomilehto; Pekka Jousilahti; Yujie Wang; Riitta Antikainen; Gang Hu Journal: Stroke Date: 2012-04-10 Impact factor: 7.914
Authors: A Kitamura; H Iso; Y Naito; M Iida; M Konishi; A R Folsom; S Sato; M Kiyama; M Nakamura; T Sankai Journal: Circulation Date: 1994-06 Impact factor: 29.690
Authors: J David Curb; Robert D Abbott; Beatriz L Rodriguez; Kamal H Masaki; Randi Chen; Jordan S Popper; Helen Petrovitch; G Webster Ross; Irwin J Schatz; Gina C Belleau; Katsuhiko Yano Journal: Am J Epidemiol Date: 2004-07-15 Impact factor: 4.897
Authors: D J Gordon; J L Probstfield; R J Garrison; J D Neaton; W P Castelli; J D Knoke; D R Jacobs; S Bangdiwala; H A Tyroler Journal: Circulation Date: 1989-01 Impact factor: 29.690
Authors: Thomas S Bowman; Howard D Sesso; Jing Ma; Tobias Kurth; Carlos S Kase; Meir J Stampfer; J Michael Gaziano Journal: Stroke Date: 2003-11-13 Impact factor: 7.914
Authors: Subroto Acharjee; William E Boden; Pamela M Hartigan; Koon K Teo; David J Maron; Steven P Sedlis; William Kostuk; John A Spertus; Marcin Dada; Bernard R Chaitman; G B John Mancini; William S Weintraub Journal: J Am Coll Cardiol Date: 2013-08-21 Impact factor: 24.094