Perinatal Infections: An Important Etiological Risk Factor for Mineralizing Angiopathy.

Though mineralizing angiopathy is increasingly being recognised as a cause of ischemic stroke in young children, it's cause is not clear. As congenital infections and perinatal infections have been proposed to be associated with mineralizing angiopathy, the authors studied the prevalence of perinatal infections in children with mineralizing angiopathy and compared it with focal cerebral arteriopathy and non-stroke patients. Sixteen children with mineralizing angiopathy, 14 children with focal cerebral arteriopathy and 40 non-stroke patients were enrolled. Detailed parental interview was conducted to look for perinatal infection [Premature rupture of membranes (PROM) and neonatal sepsis]. Perinatal infection (PROM in 8 and documented neonatal sepsis in 2) was seen in 8 patients (68.2%) with mineralizing angiopathy and none of the children with focal cerebral arteriopathy. Only 3 (7.5%) of non-stroke patients had history of PROM. This difference was statistically significant. Perinatal infections could be an important etiological risk factor seen in children with mineralizing angiopathy.