Hong-Xia Li1, Lu Gao1, Yue Yuan2. 1. Department of Cardiology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China. 2. Department of Cardiology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China. yuanyuebj22@126.com.
Abstract
BACKGROUND: Vasovagal syncope (VVS) accounts for 60-80% of cases of neurally mediated syncope. VVS results from acute orthostatic intolerance and recurrent syncopal attacks, which can seriously affect an individual's quality of life. In addition, some children even experience trauma during attacks. Therefore, it is particularly important to clarify the pathogenesis of VVS. The aim of our study is to reveal the latest research progress of VVS. DATA SOURCES: Literature that involved the pathogenesis of VVS were selected from Cochrane Library (1990-2019), EMBASE (1991-2019) and PubMed (1968-2019) databases. RESULTS: Hypovolemia, autonomic dysfunction, vasomotor dysfunction, baroreceptor reflex abnormalities, endothelial dysfunction, serotonin surges, and gut microbiota were involved in the underlying mechanism of VVS. CONCLUSIONS: VVS is not always a benign prognosis. Various aspects were involved in its pathogenesis. Bezold-Jarish reflex, dysfunction of the autonomic nervous system, genetic factors and so on played important roles in VVS; however, the mechanism remains unclear.
BACKGROUND:Vasovagal syncope (VVS) accounts for 60-80% of cases of neurally mediated syncope. VVS results from acute orthostatic intolerance and recurrent syncopal attacks, which can seriously affect an individual's quality of life. In addition, some children even experience trauma during attacks. Therefore, it is particularly important to clarify the pathogenesis of VVS. The aim of our study is to reveal the latest research progress of VVS. DATA SOURCES: Literature that involved the pathogenesis of VVS were selected from Cochrane Library (1990-2019), EMBASE (1991-2019) and PubMed (1968-2019) databases. RESULTS:Hypovolemia, autonomic dysfunction, vasomotor dysfunction, baroreceptor reflex abnormalities, endothelial dysfunction, serotonin surges, and gut microbiota were involved in the underlying mechanism of VVS. CONCLUSIONS: VVS is not always a benign prognosis. Various aspects were involved in its pathogenesis. Bezold-Jarish reflex, dysfunction of the autonomic nervous system, genetic factors and so on played important roles in VVS; however, the mechanism remains unclear.
Authors: Julian M Stewart; Marvin S Medow; Richard Sutton; Paul Visintainer; David L Jardine; Wouter Wieling Journal: J Am Heart Assoc Date: 2017-01-18 Impact factor: 5.501
Authors: Nicola Magnavita; Reparata Rosa Di Prinzio; Gabriele Arnesano; Anna Cerrina; Maddalena Gabriele; Sergio Garbarino; Martina Gasbarri; Angela Iuliano; Marcella Labella; Carmela Matera; Igor Mauro; Franca Barbic Journal: Int J Environ Res Public Health Date: 2021-11-23 Impact factor: 3.390