Ismail Yilmaz1, Bulent Evren Erkul2, Sule Ozturk Sari3, Gizem Issin4, Ersin Tural5, Neslihan Terzi Kaya Terzi6, Huseyin Karatay3, Mehmet Celik7, Murat Ulusan7, Bilge Bilgic3. 1. Department of Pathology, Sultan Abdulhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Electronic address: drisyilmaz@gmail.com. 2. Department of Otorhinolaryngology, Gulhane Medical School, Sultan Abdulhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. 3. Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. 4. Department of Pathology, Mengucek Gazi Education and Research Hospital, Erzincan University, Erzincan, Turkey. 5. Department of Pediatrics, Sultan Abdulhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. 6. Department of Pathology, Sultan Abdulhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. 7. Department of Otorhinolaryngology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Abstract
OBJECTIVE: The aim of the present study was to assess the prevalence of TERT promoter region mutations in tumor samples of patients with squamous cell carcinoma at different sites of the head and neck region and correlate it with patients' clinicopathologic data. STUDY DESIGN: Mutations in promoter region of the TERT gene were analyzed with polymerase chain reaction-based direct sequencing method using formalin-fixed, paraffin-embedded tumor samples of 189 HNSCCs. TERT promoter region mutations were assessed in terms of age, gender, location, smoking, alcohol consumption, and overall survival. RESULTS: TERT promoter region mutations were detected in the oral cavity (75%); larynx (8.4%), hypopharynx (16.6%), and oropharynx (0%). TERT promoter region mutations are associated with younger age and female gender and have a reverse relationship with smoking and alcohol consumption. CONCLUSIONS: We found statistically significant higher rates of TERT promoter region mutations in tumor samples of patients with squamous cell carcinoma in the oral cavity compared with other locations in the head and neck region.
OBJECTIVE: The aim of the present study was to assess the prevalence of TERT promoter region mutations in tumor samples of patients with squamous cell carcinoma at different sites of the head and neck region and correlate it with patients' clinicopathologic data. STUDY DESIGN: Mutations in promoter region of the TERT gene were analyzed with polymerase chain reaction-based direct sequencing method using formalin-fixed, paraffin-embedded tumor samples of 189 HNSCCs. TERT promoter region mutations were assessed in terms of age, gender, location, smoking, alcohol consumption, and overall survival. RESULTS: TERT promoter region mutations were detected in the oral cavity (75%); larynx (8.4%), hypopharynx (16.6%), and oropharynx (0%). TERT promoter region mutations are associated with younger age and female gender and have a reverse relationship with smoking and alcohol consumption. CONCLUSIONS: We found statistically significant higher rates of TERT promoter region mutations in tumor samples of patients with squamous cell carcinoma in the oral cavity compared with other locations in the head and neck region.
Authors: Marcin M Machnicki; Anna Rzepakowska; Joanna I Janowska; Monika Pepek; Alicja Krop; Katarzyna Pruszczyk; Piotr Stawinski; Malgorzata Rydzanicz; Jakub Grzybowski; Barbara Gornicka; Maciej Wnuk; Rafal Ploski; Ewa Osuch-Wojcikiewicz; Tomasz Stoklosa Journal: Front Oncol Date: 2022-05-19 Impact factor: 5.738
Authors: Silvia Giunco; Paolo Boscolo-Rizzo; Enrica Rampazzo; Giancarlo Tirelli; Lara Alessandrini; Roberto Di Carlo; Marco Rossi; Piero Nicolai; Anna Menegaldo; Valentina Carraro; Margherita Tofanelli; Luigia Bandolin; Giacomo Spinato; Enzo Emanuelli; Monica Mantovani; Marco Stellin; Rossana Bussani; Angelo Paolo Dei Tos; Maria Guido; Marzia Morello; Jonathan Fussey; Giovanni Esposito; Jerry Polesel; Anita De Rossi Journal: Front Oncol Date: 2021-11-10 Impact factor: 6.244