Literature DB >> 32402470

007 (x2)-3-3: 14-3-3 Targeted Compounds as Double Agents.

Mary Gannon1, Talene A Yacoubian2.   

Abstract

14-3-3 Proteins enact a range of cellular functions through protein-protein interactions (PPIs) with client proteins. Kaplan and colleagues recently demonstrated that a semisynthetic compound was able to selectively stabilize or disrupt specific interactions, depending on the binding partner. This finding presents an exciting possibility of designing other 14-3-3 compounds to regulate critical 14-3-3 interactions.
Copyright © 2020 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  14-3-3; axonal injury; fusicoccin-A; protein–protein interactions

Mesh：

Substances：

Year:  2020        PMID： 32402470      PMCID： PMC7478911          DOI： 10.1016/j.tips.2020.05.001

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  10 in total

Review 1.  Unlocking the code of 14-3-3.

Authors:  Michele K Dougherty; Deborah K Morrison
Journal:  J Cell Sci       Date:  2004-04-15       Impact factor: 5.285

Review 2.  Rap1, a mercenary among the Ras-like GTPases.

Authors:  E W Frische; F J T Zwartkruis
Journal:  Dev Biol       Date:  2010-01-07       Impact factor: 3.582

3.  14-3-3 Proteins Reduce Cell-to-Cell Transfer and Propagation of Pathogenic α-Synuclein.

Authors:  Bing Wang; Rachel Underwood; Anjali Kamath; Colleen Britain; Michael B McFerrin; Pamela J McLean; Laura A Volpicelli-Daley; Robert H Whitaker; William J Placzek; Katelyn Becker; Jiyan Ma; Talene A Yacoubian
Journal:  J Neurosci       Date:  2018-08-09       Impact factor: 6.167

4.  Small-Molecule Stabilization of 14-3-3 Protein-Protein Interactions Stimulates Axon Regeneration.

Authors:  Andrew Kaplan; Barbara Morquette; Antje Kroner; SooYuen Leong; Carolin Madwar; Ricardo Sanz; Sara L Banerjee; Jack Antel; Nicolas Bisson; Samuel David; Alyson E Fournier
Journal:  Neuron       Date:  2017-03-08       Impact factor: 17.173

Review 5.  Fusicoccanes: diterpenes with surprising biological functions.

Authors:  Albertus H de Boer; Ingrid J de Vries-van Leeuwen
Journal:  Trends Plant Sci       Date:  2012-03-30       Impact factor: 18.313

6.  Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.

Authors:  Andrew Kaplan; Sebastian A Andrei; Anna van Regteren Altena; Tristan Simas; Sara L Banerjee; Nobuo Kato; Nicolas Bisson; Yusuke Higuchi; Christian Ottmann; Alyson E Fournier
Journal:  Cell Chem Biol       Date:  2020-03-26       Impact factor: 8.116

7.  14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.

Authors:  Nicholas J Lavalley; Sunny R Slone; Huiping Ding; Andrew B West; Talene A Yacoubian
Journal:  Hum Mol Genet       Date:  2015-11-05       Impact factor: 6.150

8.  PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.

Authors:  Laura Civiero; Susanna Cogo; Anneleen Kiekens; Claudia Morganti; Isabella Tessari; Evy Lobbestael; Veerle Baekelandt; Jean-Marc Taymans; Marie-Christine Chartier-Harlin; Cinzia Franchin; Giorgio Arrigoni; Patrick A Lewis; Giovanni Piccoli; Luigi Bubacco; Mark R Cookson; Paolo Pinton; Elisa Greggio
Journal:  Front Mol Neurosci       Date:  2017-12-14       Impact factor: 5.639

9.  Dysregulation of 14-3-3 proteins in neurodegenerative diseases with Lewy body or Alzheimer pathology.

Authors:  Michael B McFerrin; Xiaofei Chi; Gary Cutter; Talene A Yacoubian
Journal:  Ann Clin Transl Neurol       Date:  2017-06-07       Impact factor: 4.511

Review 10.  14-3-3 Proteins in Brain Development: Neurogenesis, Neuronal Migration and Neuromorphogenesis.

Authors:  Brett Cornell; Kazuhito Toyo-Oka
Journal:  Front Mol Neurosci       Date:  2017-10-12       Impact factor: 5.639
  10 in total

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