Literature DB >> 32402415

Genetic Safeguards for Safety-by-design: So Close Yet So Far.

Enrique Asin-Garcia1, Amalia Kallergi2, Laurens Landeweerd2, Vitor A P Martins Dos Santos3.   

Abstract

Safety-by-design (SbD) is paramount for risk management in synthetic biology, with genetic safeguards being a key technology for its implementation. While attractive in theory, the integration of genetic safeguards into SbD strategies is rarely exercised in practice, despite technological advances. Here we question why and what might be done about it.
Copyright © 2020. Published by Elsevier Ltd.

Keywords:  biocontainment; biosafety; genetic safeguards; safety-by-design; synthetic biology

Year:  2020        PMID： 32402415     DOI： 10.1016/j.tibtech.2020.04.005

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN： 0167-7799            Impact factor:   19.536


  9 in total

1.  Symbiosis and the Anthropocene.

Authors:  Erik F Y Hom; Alexandra S Penn
Journal:  Symbiosis       Date:  2021-09-03       Impact factor: 3.109

2.  Bottlenecks and opportunities for synthetic biology biosafety standards.

Authors:  Lei Pei; Michele Garfinkel; Markus Schmidt
Journal:  Nat Commun       Date:  2022-04-21       Impact factor: 17.694

Review 3.  The transition of Rhodobacter sphaeroides into a microbial cell factory.

Authors:  Enrico Orsi; Jules Beekwilder; Gerrit Eggink; Servé W M Kengen; Ruud A Weusthuis
Journal:  Biotechnol Bioeng       Date:  2020-10-23       Impact factor: 4.530

4.  Value Conflicts in Designing for Safety: Distinguishing Applications of Safe-by-Design and the Inherent Safety Principles.

Authors:  Britte Bouchaut; Lotte Asveld; Ulf Hanefeld; Alexander Vlierboom
Journal:  Int J Environ Res Public Health       Date:  2021-02-18       Impact factor: 3.390

5.  Responsible Learning About Risks Arising from Emerging Biotechnologies.

Authors:  Britte Bouchaut; Lotte Asveld
Journal:  Sci Eng Ethics       Date:  2021-03-29       Impact factor: 3.525

6.  Context matters: On the road to responsible biosafety technologies in synthetic biology.

Authors:  Amalia Kallergi; Enrique Asin-Garcia; Vitor Ap Martins Dos Santos; Laurens Landeweerd
Journal:  EMBO Rep       Date:  2020-12-28       Impact factor: 9.071

7.  ReScribe: An Unrestrained Tool Combining Multiplex Recombineering and Minimal-PAM ScCas9 for Genome Recoding Pseudomonas putida.

Authors:  Enrique Asin-Garcia; Maria Martin-Pascual; Luis Garcia-Morales; Richard van Kranenburg; Vitor A P Martins Dos Santos
Journal:  ACS Synth Biol       Date:  2021-09-22       Impact factor: 5.110

8.  Phosphite synthetic auxotrophy as an effective biocontainment strategy for the industrial chassis Pseudomonas putida.

Authors:  Enrique Asin-Garcia; Christos Batianis; Yunsong Li; James D Fawcett; Ivar de Jong; Vitor A P Martins Dos Santos
Journal:  Microb Cell Fact       Date:  2022-08-08       Impact factor: 6.352

Review 9.  Safe-by-Design in Engineering: An Overview and Comparative Analysis of Engineering Disciplines.

Authors:  Pieter van Gelder; Pim Klaassen; Behnam Taebi; Bart Walhout; Ruud van Ommen; Ibo van de Poel; Zoe Robaey; Lotte Asveld; Ruud Balkenende; Frank Hollmann; Erik Jan van Kampen; Nima Khakzad; Robbert Krebbers; Jos de Lange; Wolter Pieters; Karel Terwel; Eelco Visser; Tiny van der Werff; Dick Jung
Journal:  Int J Environ Res Public Health       Date:  2021-06-11       Impact factor: 3.390
  9 in total

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