Literature DB >> 32400780

Ribosomal incorporation of cyclic β-amino acids into peptides using in vitro translation.

Joongoo Lee1, Rafael Torres1, Do Soon Kim1, Michelle Byrom2, Andrew D Ellington2, Michael C Jewett1.   

Abstract

We demonstrate in vitro incorporation of cyclic β-amino acids into peptides by the ribosome through genetic code reprogramming. Further, we show that incorporation efficiency can be increased through the addition of elongation factor P.

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Year:  2020        PMID: 32400780     DOI: 10.1039/d0cc02121k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  2 in total

1.  In vitro-Constructed Ribosomes Enable Multi-site Incorporation of Noncanonical Amino Acids into Proteins.

Authors:  Yi Liu; Roderick G Davis; Paul M Thomas; Neil L Kelleher; Michael C Jewett
Journal:  Biochemistry       Date:  2021-01-11       Impact factor: 3.162

Review 2.  Cell-free systems for accelerating glycoprotein expression and biomanufacturing.

Authors:  Jasmine Hershewe; Weston Kightlinger; Michael C Jewett
Journal:  J Ind Microbiol Biotechnol       Date:  2020-10-22       Impact factor: 3.346

  2 in total

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