Junko Tokuno1, Toru Oga2, Toyofumi F Chen-Yoshikawa3, Takahiro Oto4, Tomoyo Okawa4, Yoshinori Okada5, Miki Akiba6, Masaki Ikeda1, Satona Tanaka1, Yoshito Yamada1, Yojiro Yutaka1, Akihiro Ohsumi1, Daisuke Nakajima1, Masatsugu Hamaji1, Maki Isomi1, Kazuo Chin7, Hiroshi Date1. 1. Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. 2. Department of Respiratory Medicine, Kawasaki Medical School, Kurashiki, Japan. 3. Department of Thoracic Surgery, Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan. tyoshikawa@med.nagoya-u.ac.jp. 4. Organ Transplant Center, Okayama University Hospital, Okayama, Japan. 5. Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. 6. Division of Organ Transplantation, Tohoku University Hospital, Sendai, Japan. 7. Department of Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Abstract
PURPOSE: Poor quality of sleep is a common feature in patients with various lung diseases and affects their health-related quality of life (HRQL). We evaluated sleep quality and HRQL in patients on the waitlist for lung transplantation in Japan. METHODS: In this prospective study, patient-reported and physiological data were collected from patients newly registered on the waitlist for lung transplantation in Japan. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI) and HRQL using the St. George's Respiratory Questionnaire (SGRQ). The frequency of poor sleep quality, correlations between sleep quality and various clinical parameters, and predictive factors of sleep quality were examined. RESULTS: Of 193 patients, the three most-frequent indications for lung transplantation were interstitial pneumonia (n = 96), pulmonary complications of hematopoietic stem cell transplantation (n = 25), and pulmonary hypertension (n = 17). Poor sleep quality (PSQI > 5) was observed in 102 patients (53%) and was significantly associated with worse Hospital Anxiety and Depression Score (HADS), worse SGRQ score, worse modified Medical Research Council Dyspnea score, and shorter 6-min walk distance. However, it was not associated with sex, pulmonary function, interstitial pneumonia, or arterial blood gas. Stepwise multiple regression analysis indicated that poor sleep quality was explained significantly by HADS anxiety (23%) and SGRQ Symptoms (10%). CONCLUSION: Poor sleep quality was found to be common among patients on the lung transplantation waitlist in Japan. The two most significant factors responsible for impaired sleep quality were anxiety and respiratory symptoms. Additional care should be taken to ensuring a better quality of sleep for such patients.
PURPOSE: Poor quality of sleep is a common feature in patients with various lung diseases and affects their health-related quality of life (HRQL). We evaluated sleep quality and HRQL in patients on the waitlist for lung transplantation in Japan. METHODS: In this prospective study, patient-reported and physiological data were collected from patients newly registered on the waitlist for lung transplantation in Japan. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI) and HRQL using the St. George's Respiratory Questionnaire (SGRQ). The frequency of poor sleep quality, correlations between sleep quality and various clinical parameters, and predictive factors of sleep quality were examined. RESULTS: Of 193 patients, the three most-frequent indications for lung transplantation were interstitial pneumonia (n = 96), pulmonary complications of hematopoietic stem cell transplantation (n = 25), and pulmonary hypertension (n = 17). Poor sleep quality (PSQI > 5) was observed in 102 patients (53%) and was significantly associated with worse Hospital Anxiety and Depression Score (HADS), worse SGRQ score, worse modified Medical Research Council Dyspnea score, and shorter 6-min walk distance. However, it was not associated with sex, pulmonary function, interstitial pneumonia, or arterial blood gas. Stepwise multiple regression analysis indicated that poor sleep quality was explained significantly by HADS anxiety (23%) and SGRQ Symptoms (10%). CONCLUSION: Poor sleep quality was found to be common among patients on the lung transplantation waitlist in Japan. The two most significant factors responsible for impaired sleep quality were anxiety and respiratory symptoms. Additional care should be taken to ensuring a better quality of sleep for such patients.
Entities:
Keywords:
Health-related quality of life (HRQL); Lung transplantation; Pittsburgh Sleep Quality Index (PSQI); Sleep quality; St. George’s Respiratory Questionnaire (SGRQ)
Authors: Jeanne Geiger-Brown; Sarah Lindberg; Samuel Krachman; Charlene E McEvoy; Gerard J Criner; John E Connett; Richard K Albert; Steven M Scharf Journal: Int J Chron Obstruct Pulmon Dis Date: 2015-02-20
Authors: Makayla Cordoza; Brittany Koons; Michael L Perlis; Brian J Anderson; Joshua M Diamond; Barbara Riegel Journal: Transplant Rev (Orlando) Date: 2021-09-14 Impact factor: 3.943