Literature DB >> 32399513

The Need for Artificial Intelligence in Digital Therapeutics.

Adam Palanica1, Michael J Docktor2, Michael Lieberman1, Yan Fossat1.   

Abstract

Digital therapeutics is a newly described concept in healthcare which is proposed to change patient behavior and treat medical conditions using a variety of digital technologies. However, the term is rarely defined with criteria that make it distinct from simply digitizedversions of traditional therapeutics. Our objective is to describe a more valuable characteristic of digital therapeutics, which is distinct from traditional medicine or therapy: that is, the utilization of artificial intelligence and machine learning systems to monitor and predict individual patient symptom data in an adaptive clinical feedback loop via digital biomarkers to provide a precision medicine approach to healthcare. Artificial intelligence platforms can learn and predict effective interventions for individuals using a multitude of personal variables to provide a customized and more tailored therapy regimen. Digital therapeutics coupled with artificial intelligence and machine learning also allows more effective clinical observations and management at the population level for various health conditions and cohorts. This vital differentiation of digital therapeutics compared to other forms of therapeutics enables a more personalized form of healthcare that actively adapts to patients' individual clinical needs, goals, and lifestyles. Importantly, these characteristics are what needs to be emphasized to patients, physicians, and policy makers to advance the entire field of digital healthcare.
Copyright © 2020 by S. Karger AG, Basel.

Entities:  

Keywords:  Artificial intelligence; Digital biomarkers; Digital medicine; Digital therapeutics; Machine learning; Precision medicine

Year:  2020        PMID: 32399513      PMCID: PMC7204774          DOI: 10.1159/000506861

Source DB:  PubMed          Journal:  Digit Biomark        ISSN: 2504-110X


  12 in total

1.  Wearable devices as facilitators, not drivers, of health behavior change.

Authors:  Mitesh S Patel; David A Asch; Kevin G Volpp
Journal:  JAMA       Date:  2015-02-03       Impact factor: 56.272

Review 2.  Wearables and the medical revolution.

Authors:  Jessilyn Dunn; Ryan Runge; Michael Snyder
Journal:  Per Med       Date:  2018-09-27       Impact factor: 2.512

3.  Safety of a Hybrid Closed-Loop Insulin Delivery System in Patients With Type 1 Diabetes.

Authors:  Richard M Bergenstal; Satish Garg; Stuart A Weinzimer; Bruce A Buckingham; Bruce W Bode; William V Tamborlane; Francine R Kaufman
Journal:  JAMA       Date:  2016-10-04       Impact factor: 56.272

Review 4.  Digital Therapeutics: An Integral Component of Digital Innovation in Drug Development.

Authors:  Oleksandr Sverdlov; Joris van Dam; Kristin Hannesdottir; Tricia Thornton-Wells
Journal:  Clin Pharmacol Ther       Date:  2018-02-23       Impact factor: 6.875

Review 5.  Pharmaceutical Perspective: How Digital Biomarkers and Contextual Data Will Enable Therapeutic Environments.

Authors:  Carlos Rodarte
Journal:  Digit Biomark       Date:  2017-08-17

6.  Multivariable adaptive closed-loop control of an artificial pancreas without meal and activity announcement.

Authors:  Kamuran Turksoy; Elif Seyma Bayrak; Lauretta Quinn; Elizabeth Littlejohn; Ali Cinar
Journal:  Diabetes Technol Ther       Date:  2013-04-01       Impact factor: 6.118

7.  Closed-loop artificial pancreas systems: engineering the algorithms.

Authors:  Francis J Doyle; Lauren M Huyett; Joon Bok Lee; Howard C Zisser; Eyal Dassau
Journal:  Diabetes Care       Date:  2014       Impact factor: 19.112

Review 8.  Can composite digital monitoring biomarkers come of age? A framework for utilization.

Authors:  Christopher Kovalchick; Rhea Sirkar; Oliver B Regele; Lampros C Kourtis; Marie Schiller; Howard Wolpert; Rhett G Alden; Graham B Jones; Justin M Wright
Journal:  J Clin Transl Sci       Date:  2017-12

Review 9.  Impact of remote patient monitoring on clinical outcomes: an updated meta-analysis of randomized controlled trials.

Authors:  Benjamin Noah; Michelle S Keller; Sasan Mosadeghi; Libby Stein; Sunny Johl; Sean Delshad; Vartan C Tashjian; Daniel Lew; James T Kwan; Alma Jusufagic; Brennan M R Spiegel
Journal:  NPJ Digit Med       Date:  2018-01-15

10.  Automated psychological therapy using immersive virtual reality for treatment of fear of heights: a single-blind, parallel-group, randomised controlled trial.

Authors:  Daniel Freeman; Polly Haselton; Jason Freeman; Bernhard Spanlang; Sameer Kishore; Emily Albery; Megan Denne; Poppy Brown; Mel Slater; Alecia Nickless
Journal:  Lancet Psychiatry       Date:  2018-07-11       Impact factor: 27.083

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  8 in total

1.  Anticipating Ambulatory Automation: Potential Applications of Administrative and Clinical Automation in Outpatient Healthcare Delivery.

Authors:  Kevin Yang; Vinod E Nambudiri
Journal:  Appl Clin Inform       Date:  2021-12-29       Impact factor: 2.342

Review 2.  Digital Biomarkers in Psychiatric Research: Data Protection Qualifications in a Complex Ecosystem.

Authors:  Andrea Parziale; Deborah Mascalzoni
Journal:  Front Psychiatry       Date:  2022-06-09       Impact factor: 5.435

3.  Public R&D Projects-Based Investment and Collaboration Framework for an Overarching South Korean National Strategy of Personalized Medicine.

Authors:  Doyeon Lee; Keunhwan Kim
Journal:  Int J Environ Res Public Health       Date:  2022-01-24       Impact factor: 3.390

Review 4.  Wearable devices for continuous monitoring of biosignals: Challenges and opportunities.

Authors:  Tucker Stuart; Jessica Hanna; Philipp Gutruf
Journal:  APL Bioeng       Date:  2022-04-13

5.  A randomised pilot trial of virtual reality-based relaxation for enhancement of perioperative well-being, mood and quality of life.

Authors:  Matthias C Schrempf; Julian Petzold; Morten Aa Petersen; Tim Tobias Arndt; Stefan Schiele; Hugo Vachon; Dmytro Vlasenko; Sebastian Wolf; Matthias Anthuber; Gernot Müller; Florian Sommer
Journal:  Sci Rep       Date:  2022-07-14       Impact factor: 4.996

Review 6.  Benefits of Digital Mental Health Care Interventions for Correctional Workers and Other Public Safety Personnel: A Narrative Review.

Authors:  Elnaz Moghimi; Yuliya Knyahnytska; Mohsen Omrani; Niloofar Nikjoo; Callum Stephenson; Gina Layzell; Alexander Ian Frederic Simpson; Nazanin Alavi
Journal:  Front Psychiatry       Date:  2022-07-08       Impact factor: 5.435

7.  Clinical Evaluation of Digital Therapeutics: Present and Future.

Authors:  Ki Young Huh; Jaeseong Oh; SeungHwan Lee; Kyung-Sang Yu
Journal:  Healthc Inform Res       Date:  2022-07-31

8.  Effects of Short-term Mobile Application Use on Weight Reduction for Patients with Type 2 Diabetes.

Authors:  Seung Eun Lee; Su-Kyung Park; Ye-Seul Park; Kyoung-Ah Kim; Han Seok Choi; Sang Woo Oh
Journal:  J Obes Metab Syndr       Date:  2021-12-30
  8 in total

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