| Literature DB >> 32398875 |
Mingfeng Liao1, Yang Liu1, Jing Yuan2, Yanling Wen1, Gang Xu1, Juanjuan Zhao1, Lin Cheng1, Jinxiu Li2, Xin Wang1, Fuxiang Wang2, Lei Liu3,4, Ido Amit5, Shuye Zhang6, Zheng Zhang7,8.
Abstract
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.Entities:
Mesh：
Year: 2020 PMID： 32398875 DOI： 10.1038/s41591-020-0901-9
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440