The prevalence, characteristics, and related factors of pressure injury in medical staff wearing personal protective equipment against COVID-19 in China: A multicentre cross-sectional survey.

Since December 2019, the medical staff fighting against COVID-19 frequently reported the device-related pressure injury (DRPI) caused by personal protective equipment (PPE). We conducted a cross-sectional survey online to investigate the prevalence and characteristics of DRPI among medical staff. Univariate and multivariate logistic regression analyses were employed to explore the risk factors associated with DRPI. A total of 4308 participants were collected and 4306 participants were valid from 161 hospitals in China. The overall prevalence of DRPI caused by PPE among medical staff was 30.03% (95% CI 28.69%-31.41%). The prevalence of male was more than that of female (42.25%, 95% CI 37.99-46.51% vs 26.36%, 95% CI 26.93-29.80%, P < .001).The categories were mainly stages 1 and 2, and the common anatomical locations were nose bridge, cheeks, ears, and forehead. Logistic regression analysis revealed that the risk factors were sweating (OR = 43.99, 95% CI 34.46-56.17), male (OR = 1.50, 95% CI 1.12-1.99), level 3 PPE (OR = 1.44, 95% CI 1.14-1.83), and longer wearing time (OR = 1.28, 95% CI 0.97-1.68). The prevalence of DRPI was high among medical staff wearing PPE against COVID-19, and the risk factors were sweating, male, wearing level 3 PPE, and longer wearing time. Comprehensive preventive interventions should be taken.

INTRODUCTION

In December 2019, COVID‐19 erupted in Wuhan, China, and spread quickly across the country. More than 80 000 people were infected, and 4000 over people were killed by the disease, so the crisis event has become the largest public health emergency in China. The Chinese government continuously revised and issued programs to strengthen the prevention and control of the epidemic to reduce the mortality rate. , Early studies showed that both COVID‐19 patients and asymptomatic virus carriers could transmit from person to person. The incubation period was 1 to 14 days, and the median incubation period was 4 days, which had impact on the rapid spread of COVID‐19 virus. More than 40 000 medical staff (nurses and doctors) volunteered to fight against the spread of the COVID‐19 by wearing personal protective equipment (PPE) in accordance with infectious disease prevention and control requirements. ,

According to the guidance from the National Health Commission of the People's Republic of China, medical staff should wear different levels of PPE according to different exposure risks. The level 2 PPE included surgical masks with goggles or face masks, and protective gowns, which were mainly used to protect staff with moderate‐risk exposure positions where suspected patients were managed in emergency departments and screening clinics. The level 2 PPE characterised relatively closure with a small amount of moisture (Figure 1). The level 3 PPE included N95/KN95 respirators with goggles or face masks, and protective gowns, latex gloves, and shoes, which were mainly used to protect staff with high‐risk exposure positions in the infectious disease department, intensive care units (ICUs), and isolation wards where COVID‐19 patients were treated. The level 3 PPE characterised absolutely closure, thick, and heavy and easily cause perspiration (Figure 2).

FIGURE 1

Nurse was working in screen clinic wearing level 2 PPE. PPE, personal protective equipment

FIGURE 2

Nurse was working in ICU wearing level 3 PPE. ICUs, incentive care units; PPE, personal protective equipment

In practice, medical staff wearing PPE reported that they were easy to produce perspiration or become heavy sweating when they were working hard, which would change microclimate of skin, such as lower temperature and more moisture. Under this condition, surgical masks with goggles or N95/KN95 respirators with goggles were more easy to create mechanical forces on face skin, which contributed to skin damage and pressure injuries development (Figures 3 and 4), so an increasing number of medical staff reported skin damage on face as a result of working for 8 to 12 hours continuously wearing PPE, called device‐related pressure injuries (DRPI). , Previously, DRPI mostly occurred in critically ill patients, , , and no one reported DRPI on medical staff wearing PPE. So, we organised a multicentre cross‐sectional survey to understand the prevalence, characteristics, and related risk factors associated with DRPI among medical staff wearing PPE, and aimed to provide evidence for prevention in China, and potentially for other countries around the world.

FIGURE 3

Stage 1 DRPI on nose bridge caused by level 2 PPE. DRPI, device‐related pressure injury; PPE, personal protective equipment

FIGURE 4

Stage 3 DRPI on nose and stage1 DRPI on cheeks caused by level 3 PPE. DRPI, device‐related pressure injury; PPE, personal protective equipment

METHODS

Samples and settings

A digital survey was designed and conducted in medical staff that treated confirmed or suspected COVID‐19 patients in China. The sample size was determined based on the data of presurvey, that is, before survey we investigated 50 medical staff wearing PPE in Wuhan and other cities' hospitals, and found that 15 cases had DRPI, with a 30% prevalence, and the tolerated absolute error of 2% and with a confidence interval of 95%. The sample size calculated was 2017 participants. Considering that there may be 5% invalid questionnaires, a total of 2123 participants were needed.

Inclusion criteria included (a) medical staff who wore level 2 or 3 PPE while working at the “frontline” against COVID −19, (b) age ≧ 18 years, regardless of gender and (c) voluntary participation.

Exclusion criteria included (a) medical staff who did not wear PPE and (b) questionnaires that were incomplete or invalid.

Research tools

We designed questionnaire in consultation with relevant guides, research literature, , , , and feedback from frontline medical staff and included five topics. Topic 1 soughted general demographic information (including gender, age, current working position, and profession); topic 2 included information on the wearing of PPE (including level of PPE, daily wear time); topic 3 included skin injury information (including when the injury happened, anatomical location, pressure injury classification of either stage 1, 2, 3, 4, or deep tissue injury [DTI]). Topic 4 included information on implemented protective measures (including uses of agents or dressings). Topic 5 included management interventions after injury. The questionnaire was reviewed and revised three times in consultation with statistics experts, nursing management experts, wound care experts, and medical staff at the frontline in Wuhan.

Research methods

We uploaded the questionnaire on the “Questionnaire Star Tool” and disseminated it to the medical staff fighting with COVID‐19 via the WeChat social platform on 8 February 2020, with a completion date to be 22 February 2020. The nominated person from 12 hospitals disseminated the questionnaire link to WeChat groups of medical teams supporting Wuhan, infectious disease departments or isolation wards, and ICUs. Then enough medical staff were recruited to participate in the investigation by WeChat groups. Participants voluntarily used their cell phone to answer and submit the questionnaire response online within the 2 weeks data collection period using the “Questionnaire Star Tool.”

Quality control

In order to enable the medical staff to answer questions quickly and accurately, we provided some space for comments and multiple‐choice response to questions, such as the injury locations included the nose bridge, cheeks, ears, forehead, and others (filling in). The classification of the DRPI depended on the staging system outlined in the 2019 International Guide for Prevention and Treatment of Pressure Ulcer/Injury. During the survey period, the research team answered any question of the medical staff by cell phone or email promptly. At the end of the survey, each original questionnaire was exported from the website of the “Questionnaire Star” and checked one by one for data.

Statistical analysis

All the data were derived from the “Questionnaire Star” website, and the analysis database was established after being checked by two researchers. Continuous variables were presented as mean with SD or median with interquartile range (IQR) where necessary. Categorical variables were described as frequencies and percentages. Univariate analysis was first performed for identifying potential factors for the DRPI. Student's t tests or Mann‐Whitney U tests were used for comparing the differences between two groups for continuous or ordinal variables. Pearson's Chi‐square tests or Fisher's exact tests where applicable were used for comparing categorical variables. Those variables with probability value of P < .10 on univariate analysis were entered into multivariate logistic regression model with the backward method to establish whether they independently associated with DRPI. A P value of .05 or less was considered to indicate statistical significance. All statistical analyses were performed using SPSS 22.0 for Windows (SPSS, Chicago, IL).

RESULTS

General information of samples

The survey was completed by a total of 4308 medical staff (nurses and doctors) from 161 hospitals, in 28 provinces, autonomous regions, and municipalities in China. There were two invalid questionnaires rejected leaving a total of 4306 responses, which were analysed. There were 516 male (11.98%) and 3790 female (88.02%), and they comprised 505 doctors (11.73%) and 3801 nurses (88.27%). The average age was 32.51 ± 7.13 year old, of which 67.42% (2903/4306) were <35 year old, and 32.58% (1403/4306) were ≥35 year old. Medical staff wearing level 3 and level 2 PPE comprised 32.42% (1396/4306) and 67.58% (2910/4306), respectively. The average daily wear time was 7.67 ± 2.92 hours, daily wear time ≤4 hours and >4 hours accounted for 15.65% (674/4306) and 84.35% (3632/4306), respectively. There were 34.07% (1467/4306) of participants who reported heavy sweating while wearing PPE. Participants who reported that they used foam dressings, hydrocolloid dressings, or personal agents to protect skin under the devices accounted for 4.55% (196/4306), 9.96% (429/4306), and 6.80% (293/4306), respectively.

Prevalence and characteristics of DRPI

The survey found that the prevalence of DRPI caused by wearing PPE was 30.03% (95% CI 28.69%–31.41%), totaling 1293 cases had 3457 DRPIs. The prevalence of single DRPI was 6.64% (95% CI 5.91%‐7.40%), and multiple location DRPIs (two or more) were 23.42% (95% CI 22.22%‐24.70%) with significance (P < .001). The category of DRPIs mainly comprised stages 1 and 2, accounting for 98.84%. The nose bridge and cheeks were common anatomical locations, accounting for 59.65%, and followed by ears, forehead, and other locations, such as zygoma, mandible, and eyebrow arch. The distribution of staging and anatomical locations of DRPI is shown in Table 1.

TABLE 1

Stage and location distribution of DRPI in medical staff (number of sites = 3457, n = 1293)

Site	Cases (proportion%)				Total	Prevalence
	Stage 1	Stage 2	Stage 3	DTI		Rate (95% CI) a
Bridge of nose	859 (81.65)	181 (17.21)	5 (0.48)	7 (0.67)	1052 (100.00)	24.43 (23.15–25.71)
Cheeks	851 (84.26)	149 (14.75)	4 (0.40)	6 (0.59)	1010 (100.00)	23.46 (22.19–24.72)
Auricle	729 (83.31)	136 (15.54)	4 (0.46)	6 (0.69)	875 (100.00)	20.32 (19.12–21.52)
Forehead	395 (83.51)	72 (15.22)	3 (0.63)	3 (0.63)	473 (100.00)	10.98 (10.05–11.92)
Other b	32 (68.09)	13 (27.66)	1 (2.13)	1 (2.13)	47 (100.00)	1.09 (0.78–1.40)
Total	2866 (82.90)	551 (15.94)	17 (0.49)	23 (0.67)	3457 (100.00)

Abbreviations: DRPI, device‐related pressure injury; DTI, deep tissue injury.

These rates are the prevalence rates of DRPI for specific sites.

Other: mandible, groin, neck, and so on.

The prevalence of DRPI in male was higher than that in female (42.25% vs 28.36%, P < .001). The number of DRPI between the <35‐year‐old group and the ≥35‐year‐old group (29.35% vs 31.43%) was not significant (P > .05). Interestingly, the number of doctors with DRPI was higher than that of nurses (35.84% vs 29.26% P = .002). Furthermore, the number of cases with DRPI who wore level 3 PPE was higher than those who wore level 2 PPE (63.97% vs 13.75%, P < .001), and the number of cases with DRPI who wore PPE lasting time of >4 hours was higher than those who wore ≤4 hours (33.29% vs 12.46%, P < .001). The number of cases who reported with sweating under the PPE was higher than that without sweating. The single‐factor analysis is shown in Table 2.

TABLE 2

Characteristics of the study participants by DRPI in medical staff

Characteristics	n	Numbers of DRPI (%)	Prevalence rate (95% CI)	P value
Gender				<.001
Male	516	218	42.25 (37.99‐46.51)
Female	3790	1075	28.36 (26.93‐29.80
Age				.143
<35 years	2903	852	29.35 (27.69‐31.01)
≥35 years	1403	441	31.43 (29.00‐33.86)
Leve1 3 PPE				<.001
Yes	1396	893	63.97 (61.45‐66.49)
No	2910	400	13.75 (12.49‐15.00)
DWT				<.001
>4 hours	3632	1209	33.29 (31.75‐34.82)
≤4 hours	674	84	12.46 (9.97‐14.96)
Occupation				.002
Doctors	505	181	35.84 (31.66‐40.02)
Nurses	3801	1112	29.26 (27.81‐30.70)
Heavy sweating				<.001
Yes	1467	1136	77.44 (75.30‐79.58)
No	2839	157	5.53 (4.69‐6.37)
Total	4306	1293	30.03 (28.66‐31.40)

Abbreviations: CI, confidence interval; DRPI, device‐related pressure injury; DWT, daily wear time; PPE, personal protective equipment.

Results of logistic regression analysis

The dichotomous variable of DRPI was regressed as a dependent variable in multivariate logistic models. Entering those variables with probability value of P < .10 on univariate analysis (in Table 2) into multivariate logistic regression model, the backward method was selected to establish whether they independently associated with DRPI. The omnibus test of model coefficients was χ2 = 2501.214 (df = 4, P < .001). The Nagelkerke R 2 of model summary was 0.625, which meant that 62.5% of the observed variation of dependent variable could be explained by independent variables. A goodness of fit of the model was performed, and the result of Hosmer and Lemeshow test was χ2 = 2.728 (df = 5, P = .742). The 88.7% of participants could be classified correctly through the model. These results showed that the model could fit the data well and explain the relevant results reasonably.

The variable of occupation was removed from the final multivariate logistic model, and the sweating, daily wearing time, gender, and level of PPE were retained in the model, which were associated with the occurrence of DRPI. The results are shown in Table 3.

TABLE 3

Results of univariate and multivariate logistic analyses of DRPI in medical staff

Factors	Univariate analysis			Multivariate analysis
	OR	95% CI for OR	P value	OR	95% CI for OR	P value
Gender (male)	1.85	1.54 to 2.24	<.001	1.50	1.12 to 1.99	.006
Level 3 PPE	11.14	9.57 to 12.97	<.001	1.44	1.14 to 1.83	.002
DWT (>4 hours)	3.51	2.76 to 4.45	<.001	2.20	1.50 to 3.06	<.001
Heavy sweating	58.73	47.98 to 71.89	<.001	43.99	34.46 to 56.17	<.001
Occupation (doctors)	1.35	1.11 to 1.64	.003

Abbreviations: CI, confidence interval; DRPI, device‐related pressure injury; DWT, daily wear time; OR, odds ratio; PPE, personal protective equipment.

DISCUSSION

The prevalence and characteristics of DRPI in medical staff wearing PPE

The COVID‐19 pandemic that began in December 2019 has caused many problems worthy of global attention. However, the DRPI among medical staff wearing PPE was unexpected. More than 3000 Chinese medical staff (doctors and nurses) have been infected by the virus and more than 20 infected medical staff lost their lives from January to February in about 1 month. As a result, the Chinese government issued an emergency notice on 19th February, calling for “strengthening to protect their health and safety of medical professionals during the prevention and control of the epidemic.” Under this background, the results of this study provided insight into the scope of DPRI related to the longer wearing time for PPE and would improve interventions to further protect the health of the medical staff in China and potentially in other countries.

The data obtained from this digital online showed that the prevalence of DRPI among medical staff was as high as 30.03% (95% CI 28.69%‐31.41%), and it was significantly higher than non‐PPE‐acquired DRPI among patients in the United States and Canada, which reported a prevalence of 7.2% (n = 7189), and the facility‐acquired DRPI incidence was 3.1% (n = 3113) in 2016. Our findings were also higher than an Australian reported DRPI prevalence of 27.9% among ICU patients. Compared with the results of two systematic reviews conducted in 2019, one of which reviewed the data from 126 150 patients from 29 original studies worldwide, it was found that the pooled incidence of DRPI in adult hospitalised patients was 12% to 14%. Although another systematic review included data from 13 original studies reported that the overall incidence of DRPI was 0.69% to 14.41% in ICU patients. The prevalence of DRPI in Chinese medical staff was significantly higher than the studies reported patients' results.

The most common medical devices associated with DRPI in patients are nasal oxygen tubes, splints or plaster braces, positive pressure ventilation masks, and respiratory devices, whereas the Chinese medical staff had longer wearing times with their PPE and were under conditions of intense activity and high mental stress. Moreover, they experienced heavy sweating under the PPE and the facial compression from N95 respirators and goggles, which changed microclimate and mechanical forces on the affected skin. Furthermore, the heavy and airtight PPE made it difficult to volatilise perspiration, which could increase more moisture and microclimate on skin and decrease skin's tolerance to mechanical forces. All these factors contributed to DRPI development.

The categories of DRPIs among Chinese medical staff were mainly stages 1 and 2 (98.84%), which was higher than the result of 58% of stages 1 and 2 DRPI in the United States and Canada, but comparable to 73.82% of stages 1 and 2 DRPI reported among ICU patients, the nose bridge and cheeks were the main affected anatomical locations of DRPI (59.65%) as compared with DPRI reported on ears (29%) and feet (12%) in an international patient cohort. In China, the N95 respirators, goggles, and protective masks were the devices primarily responsible for the DRPI among medical staff. On application, the N95 respirator and goggles produced pressure on the nose bridge and cheeks and then caused DRPIs (Figure 5), and the mask strap applied pressure to cause DRPI on the ears (Figure 6). The level 3 PPE primarily affected the nose, cheeks, and forehead (Figure 7). The combined action between mechanical forces and moisture under PPE could explain why the prevalence of multiple location DRPIs was higher than single DRPI (23.42% vs6.64%, 95% CI 22.22%–24.70% vs 95% CI 5.91%‐7.40%, P < .001).

FIGURE 5

Stage 2 DRPIs on nose bridge and cheeks caused by N95 respirator and goggles. DRPI, device‐related pressure injury

FIGURE 6

Mask straps caused stage 2 DRPI on the ear. DRPI, device‐related pressure injury

FIGURE 7

Multi‐DRPIs on face caused by level 3 PPE. DRPI, device‐related pressure injury; PPE, personal protective equipment

In addition, the preventive measures employed by some medical staff proved insufficient for off‐loading purposes with foam dressings or hydrocolloid dressings, accounting for only 4.55% and 9.96%, respectively. Was it also a reason for the high prevalence of DRPI in medical staff? It is worth further study.

The related factors of DRPI in medical staff

The results of this study showed that compared with the prevalence of DRPI among different health professionals (doctors as compared to nurses), gender (male), level of PPE, and daily wearing time, sweating was significant (all P < .05‐.001) (Table 2). Logistic univariate analysis (Table 3) also showed that the above factors were associated with the occurrence of DRPI (all OR > 1, all P < .05‐.001).

The results of multivariate logistic regression analysis showed that (Table 3) sweating had a significant DRPI risk (OR 43.99, 95% CI 34.46‐56.17, P < .001), which could be associated with the wearing level 3 PPE and higher working intense. Most medical staff complained that the sweating started 30 minutes after wearing PPE: the longer the wearing time, the more the sweaty. Moreover, the level 3 PPE provided an airtight system, sweat, and water vapours from the respiratory tract were difficult to volatilise, which resulted in moisture gathering on the skin, soaked the skin for long periods, made the stratum corneum softer and thinner, and thus more susceptible to mechanical forces and increased risk of DRPI.

The increased risk of DRPI in male (OR 1.50, 95% CI 1.12‐1.99, P = .006) may be related to activity levels, hormonal differences, or a perception that Chinese men do not pay attention to use skin care products to maintain their skin health as women do. Interestingly, the increase in male with DRPI was consistent with a previous multicentre survey, which demonstrated a higher prevalence of pressure injuries in Chinese male inpatients than that of female inpatients and could suggest that male skin needs more protection, or male requires more pressure injury prevention education.

The level 3 PPE also played an important role in the increased occurrence of DRPI (OR 1.44 95% CI 1.14‐1.83, P = .002). As mentioned earlier, N95 respirators, goggles, and protective masks in level 3 PPE pressed the nose bridge, cheeks, ears, and forehead and coupled with the decrease in skin tolerance caused by perspiration and increased friction caused by rapid movement when caring for patients, so this might create a cumulative risk for DRPI. Combined with the influence of daily wearing time for PPE, we found that it was also a risk factor for DRPI (OR = 2.20, 95% CI 1.50‐3.06, P < .001).

Limitations

There were some limitations in the study, for example, because of the emergency, it was difficult to use a random sampling, there may be certain risk of sampling bias and may explain partially the high prevalence of PPE DRPI. In addition, insufficient preventive measures and most of the measures (foam and hydrocolloid dressings, oil, or cream) after injury, rather than before injury, limited our further analysis of the real preventive effect. This might leave us some chance to study further.

CONCLUSION

This study investigated a previously unreported cause of DRPI. The prevalence of DRPI in medical staff wearing PPE in China was found to be significantly high, and the main risk factors were identified to be sweating, male gender, the wearing of level 3 PPE, and longer wear times. Insufficient preventive measures and their roles in DRPI need further study. Suggestions made in this study included, firstly, it is required to evaluate the suitable daily wearing time and to limit the daily wearing time of PPE to 4 hours or less as far as possible. , Secondly, it is necessary to evaluate the feasibility and effect of preventive dressings under PPE in line with guideline recommendations. , , , , Because in the early days of wearing PPE, the use of prophylactic dressings to prevent DRPI on the face is controversial. Some people thought that the use of preventive dressing might affect the airtightness of N95 respirators and goggles and affect the protective effect. Then some people in practice found that the use of hydrocolloid dressing or silicone foam dressing on the nose, cheeks, and forehead did not affect the protective effect, but it could effectively prevent DRPI on the face (Figure 8).Therefore, this problem deserves further study. Thirdly, medical staff wearing PPE need to check their skin at least twice a day, , , , , and optimise the skin condition by using products to protect from moisture‐associated skin damage (MASD). ,

FIGURE 8

Practice of protecting skin with preventive dressings when wearing PPE: A, protect the bridge of nose, cheeks and forehead with ultra‐thin foam dressings before wearing PPE; B, wear N95 respirator and goggles; C, slight indentations on cheeks after wearing N95 respirator and goggles for 6 hours with preventive dressings; D, obvious indentations on cheeks and forehead after wearing N95 respirator and goggles for 6 hours without preventive dressings. PPE, personal protective equipment

CONFLICT OF INTEREST

The authors declared no potential conflict of interest.