Literature DB >> 32396160

A fentanyl vaccine constructed upon opsonizing antibodies specific for the Galα1-3Gal epitope.

Jiaxing Wang1, Beverly Ellis, Bin Zhou, Lisa M Eubanks, Steven Blake, Kim D Janda.   

Abstract

A double conjugation strategy was implemented to produce an anti-fentanyl vaccine, which was predicated upon preformed-antibody-assisted antigen presentation. The new vaccine was found to reduce the psychoactive effects of fentanyl without the addition of the immunostimulant CpG oligodeoxynucleotide.

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Year:  2020        PMID： 32396160      PMCID： PMC7398699          DOI： 10.1039/d0cc02107e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  28 in total

Review 1.  CpG motifs in bacterial DNA and their immune effects.

Authors:  Arthur M Krieg
Journal:  Annu Rev Immunol       Date:  2001-10-04       Impact factor: 28.527

Review 2.  Mechanisms of phagocytosis in macrophages.

Authors:  A Aderem; D M Underhill
Journal:  Annu Rev Immunol       Date:  1999       Impact factor: 28.527

3.  A STUDY OF SOME OF THE PHARMACOLOGIC ACTIONS OF FENTANYL CITRATE.

Authors:  J F GARDOCKI; J YELNOSKY
Journal:  Toxicol Appl Pharmacol       Date:  1964-01       Impact factor: 4.219

4.  Prevention of the effects of fentanyl by immunological means.

Authors:  M Torten; C H Miller; J H Eisele; G L Henderson; E Benjamini
Journal:  Nature       Date:  1975-02-13       Impact factor: 49.962

5.  A Fentanyl Vaccine Alters Fentanyl Distribution and Protects against Fentanyl-Induced Effects in Mice and Rats.

Authors:  Michael D Raleigh; Federico Baruffaldi; Samantha J Peterson; Morgan Le Naour; Theresa M Harmon; Jennifer R Vigliaturo; Paul R Pentel; Marco Pravetoni
Journal:  J Pharmacol Exp Ther       Date:  2018-11-08       Impact factor: 4.030

Review 6.  A Vision for Vaccines: Combating the Opioid Epidemic.

Authors:  Candy S Hwang; Kim D Janda
Journal:  Biochemistry       Date:  2017-10-10       Impact factor: 3.162

7.  Changes in Synthetic Opioid Involvement in Drug Overdose Deaths in the United States, 2010-2016.

Authors:  Christopher M Jones; Emily B Einstein; Wilson M Compton
Journal:  JAMA       Date:  2018-05-01       Impact factor: 56.272

8.  Combatting Synthetic Designer Opioids: A Conjugate Vaccine Ablates Lethal Doses of Fentanyl Class Drugs.

Authors:  Paul T Bremer; Atsushi Kimishima; Joel E Schlosburg; Bin Zhou; Karen C Collins; Kim D Janda
Journal:  Angew Chem Int Ed Engl       Date:  2016-02-16       Impact factor: 15.336

9.  Enhanced antigen presentation using human Fc gamma receptor (monocyte/macrophage)-specific immunogens.

Authors:  E J Gosselin; K Wardwell; D R Gosselin; N Alter; J L Fisher; P M Guyre
Journal:  J Immunol       Date:  1992-12-01       Impact factor: 5.422

Review 10.  Naloxone treatment in opioid addiction: the risks and benefits.

Authors:  Eveline L A van Dorp; Ashraf Yassen; Albert Dahan
Journal:  Expert Opin Drug Saf       Date:  2007-03       Impact factor: 4.250
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  1 in total

Review 1.  Unique Pharmacology, Brain Dysfunction, and Therapeutic Advancements for Fentanyl Misuse and Abuse.

Authors:  Ying Han; Lu Cao; Kai Yuan; Jie Shi; Wei Yan; Lin Lu
Journal:  Neurosci Bull       Date:  2022-05-15       Impact factor: 5.271
  1 in total

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