Literature DB >> 32395165

Visual Pathway Degeneration in Chemotherapy-Related Neurotoxicity: A Review and Directions for Future Research.

David E Anderson1,2,3, Sarah A Holstein3,4, Sachin Kedar1,2.   

Abstract

Chemotherapy-related neurotoxicity (CRNT) is an emerging public health concern. Visual pathway degeneration may be a symptom of CRNT. We surveyed the current literature for evidence of visual pathway degeneration in cancer patients receiving chemotherapy. A systematic review was conducted in PubMed. Six published articles met our inclusion criteria. The studies showed reduced retinal thickness, primarily in the retinal nerve fibre layer, and impaired inner retinal function in patients receiving chemotherapy. In summary, the current literature suggests chemotherapy may induce visual pathway degeneration. Future research may benefit from improving study design, exploring mechanisms of chemotherapy-related visual pathway degeneration, and incorporating these findings into biomarker development.
© 2019 Taylor & Francis Group, LLC.

Entities:  

Keywords:  Cancer; chemotherapy; electroretinography; neurotoxicity; optical coherence tomography; retina

Year:  2020        PMID： 32395165      PMCID： PMC7202439          DOI： 10.1080/01658107.2019.1702703

Source DB:  PubMed          Journal:  Neuroophthalmology        ISSN： 0165-8107


  39 in total

Review 1.  Chemobrain: a critical review and causal hypothesis of link between cytokines and epigenetic reprogramming associated with chemotherapy.

Authors:  Xiao-Min Wang; Brian Walitt; Leorey Saligan; Agnes F Y Tiwari; Chi Wai Cheung; Zhang-Jin Zhang
Journal:  Cytokine       Date:  2015-01-05       Impact factor: 3.861

2.  Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration.

Authors:  Mariacarmela Allocca; Joshua J Corrigan; Aprotim Mazumder; Kimberly R Fake; Leona D Samson
Journal:  Sci Signal       Date:  2019-02-12       Impact factor: 8.192

3.  Central Macular Thickness Monitoring after a Taxane-Based Therapy in Visually Asymptomatic Patients.

Authors:  Elias Chelala; Nicolas Arej; Joelle Antoun; Hampig Raphael Kourie; Karen Zaarour; Fady Ghassan Haddad; Fadi Farhat; Fadi El Karak; Joseph Kattan
Journal:  Chemotherapy       Date:  2017-03-29       Impact factor: 2.544

Review 4.  Mechanisms underlying select chemotherapeutic-agent-induced neuroinflammation and subsequent neurodegeneration.

Authors:  Fleur McLeary; Arie Davis; Santosh Rudrawar; Anthony Perkins; Shailendra Anoopkumar-Dukie
Journal:  Eur J Pharmacol       Date:  2018-10-01       Impact factor: 4.432

5.  Patterns of dementia diagnosis in surveillance, epidemiology, and end results breast cancer survivors who use chemotherapy.

Authors:  Julia E Heck; Steven M Albert; Rebeca Franco; Sherri Sheinfeld Gorin
Journal:  J Am Geriatr Soc       Date:  2008-08-04       Impact factor: 5.562

Review 6.  Cytokine-mediated blood brain barrier disruption as a conduit for cancer/chemotherapy-associated neurotoxicity and cognitive dysfunction.

Authors:  Hannah R Wardill; Kimberley A Mander; Ysabella Z A Van Sebille; Rachel J Gibson; Richard M Logan; Joanne M Bowen; Stephen T Sonis
Journal:  Int J Cancer       Date:  2016-07-15       Impact factor: 7.396

7.  Effects of cisplatin-5-fluorouracil combination therapy on oxidative stress, DNA damage, mitochondrial apoptosis, and death receptor signalling in retinal pigment epithelium cells.

Authors:  Hande Güçlü; Zeynep Banu Doganlar; Vuslat Pelitli Gürlü; Altan Özal; Ayten Dogan; Meryem Aysenur Turhan; Oguzhan Doganlar
Journal:  Cutan Ocul Toxicol       Date:  2018-04-19       Impact factor: 1.820

8.  The protective effects of astaxanthin against cisplatin-induced retinal toxicity.

Authors:  Hüseyin Fındık; Levent Tumkaya; Adnan Yılmaz; Mehmet Gökhan Aslan; Murat Okutucu; Kerimali Akyildiz; Tolga Mercantepe
Journal:  Cutan Ocul Toxicol       Date:  2019-01-09       Impact factor: 1.820

Review 9.  Neuroinflammation in Alzheimer's disease.

Authors:  Michael T Heneka; Monica J Carson; Joseph El Khoury; Gary E Landreth; Frederic Brosseron; Douglas L Feinstein; Andreas H Jacobs; Tony Wyss-Coray; Javier Vitorica; Richard M Ransohoff; Karl Herrup; Sally A Frautschy; Bente Finsen; Guy C Brown; Alexei Verkhratsky; Koji Yamanaka; Jari Koistinaho; Eicke Latz; Annett Halle; Gabor C Petzold; Terrence Town; Dave Morgan; Mari L Shinohara; V Hugh Perry; Clive Holmes; Nicolas G Bazan; David J Brooks; Stéphane Hunot; Bertrand Joseph; Nikolaus Deigendesch; Olga Garaschuk; Erik Boddeke; Charles A Dinarello; John C Breitner; Greg M Cole; Douglas T Golenbock; Markus P Kummer
Journal:  Lancet Neurol       Date:  2015-04       Impact factor: 44.182

10.  B-wave of the electroretinogram. A reflection of ON bipolar cell activity.

Authors:  R A Stockton; M M Slaughter
Journal:  J Gen Physiol       Date:  1989-01       Impact factor: 4.086
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