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Literature DB >> 32391434

Mechanisms of spindle bipolarity establishment in acentrosomal human cells.

Kaho Hashimoto¹, Takumi Chinen¹, Daiju Kitagawa¹.

Abstract

Centrosomes are not absolutely essential for cell division; acentrosomal bipolar spindles can be established in oocytes and centrosome-eliminated somatic cells. However, the detailed mechanisms describing how spindle bipolarity is established without centrosomes are not completely understood. We have recently demonstrated that in acentrosomal human cells, nuclear mitotic apparatus protein (NuMA) assemblies-mediated microtubule asters and EG5 promote spindle bipolarization in early mitosis.

Entities: Disease Gene Species

Keywords: Acentrosomal spindle; NuMA; spindle bipolarity

Year: 2020 PMID： 32391434 PMCID： PMC7199734 DOI： 10.1080/23723556.2020.1743899

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

15 in total

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Authors: Quansheng Du; Laura Taylor; Duane A Compton; Ian G Macara
Journal: Curr Biol Date: 2002-11-19 Impact factor: 10.834

2. Self-organization of MTOCs replaces centrosome function during acentrosomal spindle assembly in live mouse oocytes.

Authors: Melina Schuh; Jan Ellenberg
Journal: Cell Date: 2007-08-10 Impact factor: 41.582

3. A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly.

Authors: A Merdes; K Ramyar; J D Vechio; D W Cleveland
Journal: Cell Date: 1996-11-01 Impact factor: 41.582

Review 4. Kinesin-5 Regulation and Function in Mitosis.

Authors: Barbara J Mann; Patricia Wadsworth
Journal: Trends Cell Biol Date: 2018-09-13 Impact factor: 20.808

5. Stem cells: Regenerating the skin of a young patient.

Authors: Kim Baumann
Journal: Nat Rev Mol Cell Biol Date: 2017-11-29 Impact factor: 94.444

6. NuMA assemblies organize microtubule asters to establish spindle bipolarity in acentrosomal human cells.

Authors: Takumi Chinen; Shohei Yamamoto; Yutaka Takeda; Koki Watanabe; Kanako Kuroki; Kaho Hashimoto; Daisuke Takao; Daiju Kitagawa
Journal: EMBO J Date: 2019-11-29 Impact factor: 11.598

7. Human oocytes. Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytes.

Authors: Zuzana Holubcová; Martyn Blayney; Kay Elder; Melina Schuh
Journal: Science Date: 2015-06-05 Impact factor: 47.728

8. Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4.

Authors: Yao Liang Wong; John V Anzola; Robert L Davis; Michelle Yoon; Amir Motamedi; Ashley Kroll; Chanmee P Seo; Judy E Hsia; Sun K Kim; Jennifer W Mitchell; Brian J Mitchell; Arshad Desai; Timothy C Gahman; Andrew K Shiau; Karen Oegema
Journal: Science Date: 2015-04-30 Impact factor: 47.728

2. TRAF4 Inhibits the Apoptosis and Promotes the Proliferation of Breast Cancer Cells by Inhibiting the Ubiquitination of Spindle Assembly-Associated Protein Eg5.

Authors: Miaomiao Hao; Jie Zhang; Mingfang Sun; Kexin Diao; Jian Wang; Shiping Li; Qixue Cao; Shundong Dai; Xiaoyi Mi
Journal: Front Oncol Date: 2022-05-25 Impact factor: 5.738

2 in total