Literature DB >> 32391426

Lysine succinylation and SIRT5 couple nutritional status to glutamine catabolism.

Michael J Lukey1,2, Kai Su Greene1, Richard A Cerione1.   

Abstract

The metabolic microenvironment of tumors is characterized by fluctuating and limited nutrient availability. To survive these conditions, cancer cell-intrinsic mechanisms sense and signal nutritional status. We describe how glutaminase (GLS) is destabilized by lysine succinylation and stabilized by the NAD+-dependent desuccinylase sirtuin 5 (SIRT5), coupling nutrient levels to metabolic flux.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  GLS; SIRT5; cancer-metabolism; glutamine; succinylation

Year:  2020        PMID： 32391426      PMCID： PMC7199738          DOI： 10.1080/23723556.2020.1735284

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  8 in total

1.  Emerging Roles for SIRT5 in Metabolism and Cancer.

Authors:  Lauren R Bringman-Rodenbarger; Angela H Guo; Costas A Lyssiotis; David B Lombard
Journal:  Antioxid Redox Signal       Date:  2017-10-26       Impact factor: 8.401

2.  SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

Authors:  Jeongsoon Park; Yue Chen; Daniel X Tishkoff; Chao Peng; Minjia Tan; Lunzhai Dai; Zhongyu Xie; Yi Zhang; Bernadette M M Zwaans; Mary E Skinner; David B Lombard; Yingming Zhao
Journal:  Mol Cell       Date:  2013-06-27       Impact factor: 17.970

3.  Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation.

Authors:  Brian T Weinert; Christian Schölz; Sebastian A Wagner; Vytautas Iesmantavicius; Dan Su; Jeremy A Daniel; Chunaram Choudhary
Journal:  Cell Rep       Date:  2013-08-15       Impact factor: 9.423

4.  A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation.

Authors:  Gregory R Wagner; Dhaval P Bhatt; Thomas M O'Connell; J Will Thompson; Laura G Dubois; Donald S Backos; Hao Yang; Grant A Mitchell; Olga R Ilkayeva; Robert D Stevens; Paul A Grimsrud; Matthew D Hirschey
Journal:  Cell Metab       Date:  2017-04-04       Impact factor: 27.287

5.  SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.

Authors:  Kristin A Anderson; Frank K Huynh; Kelsey Fisher-Wellman; J Darren Stuart; Brett S Peterson; Jonathan D Douros; Gregory R Wagner; J Will Thompson; Andreas S Madsen; Michelle F Green; R Michael Sivley; Olga R Ilkayeva; Robert D Stevens; Donald S Backos; John A Capra; Christian A Olsen; Jonathan E Campbell; Deborah M Muoio; Paul A Grimsrud; Matthew D Hirschey
Journal:  Cell Metab       Date:  2017-04-04       Impact factor: 27.287

Review 6.  Mitochondrial sirtuins and their relationships with metabolic disease and cancer.

Authors:  Surinder Kumar; David B Lombard
Journal:  Antioxid Redox Signal       Date:  2015-02-10       Impact factor: 8.401

7.  c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism.

Authors:  Ping Gao; Irina Tchernyshyov; Tsung-Cheng Chang; Yun-Sil Lee; Kayoko Kita; Takafumi Ochi; Karen I Zeller; Angelo M De Marzo; Jennifer E Van Eyk; Joshua T Mendell; Chi V Dang
Journal:  Nature       Date:  2009-02-15       Impact factor: 49.962

Review 8.  SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis.

Authors:  Yueming Zhu; Yufan Yan; Daniel R Principe; Xianghui Zou; Athanassios Vassilopoulos; David Gius
Journal:  Cancer Metab       Date:  2014-10-20
  8 in total
  2 in total

Review 1.  Oncometabolites drive tumorigenesis by enhancing protein acylation: from chromosomal remodelling to nonhistone modification.

Authors:  Yidian Fu; Jie Yu; Fang Li; Shengfang Ge
Journal:  J Exp Clin Cancer Res       Date:  2022-04-15

2.  SIRT5-Related Desuccinylation Modification Contributes to Quercetin-Induced Protection against Heart Failure and High-Glucose-Prompted Cardiomyocytes Injured through Regulation of Mitochondrial Quality Surveillance.

Authors:  Xing Chang; Tian Zhang; Junyan Wang; Yan Liu; Peizheng Yan; Qingyan Meng; Yongtian Yin; Shiyuan Wang
Journal:  Oxid Med Cell Longev       Date:  2021-09-23       Impact factor: 6.543
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.