Literature DB >> 32391417

Targeting the oncogenic activity of TCF3-HLF in leukemia.

Yun Huang1, Jean-Pierre Bourquin1.   

Abstract

The oncogenic fusion transcription factor TCF3-HLF identifies an aggressive subtype of acute lymphoblastic leukemia. TCF3-HLF imposes a malignant program by activation of lineage-specific oncogenic enhancers. Among critical cofactors of the TCF3-HLF complex we identified EP300, which functional inhibition results in potent anti-leukemic activity by interference with the specific gene expression.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  Leukemia; TCF3-HLF; chimeric transcription factor; drug resistance; enhancer

Year:  2020        PMID： 32391417      PMCID： PMC7199759          DOI： 10.1080/23723556.2019.1709391

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Global polio eradication: not there yet.

Authors: 
Journal:  Lancet       Date:  2013-01-05       Impact factor: 79.321

2.  A 17-gene stemness score for rapid determination of risk in acute leukaemia.

Authors:  Stanley W K Ng; Amanda Mitchell; James A Kennedy; Weihsu C Chen; Jessica McLeod; Narmin Ibrahimova; Andrea Arruda; Andreea Popescu; Vikas Gupta; Aaron D Schimmer; Andre C Schuh; Karen W Yee; Lars Bullinger; Tobias Herold; Dennis Görlich; Thomas Büchner; Wolfgang Hiddemann; Wolfgang E Berdel; Bernhard Wörmann; Meyling Cheok; Claude Preudhomme; Herve Dombret; Klaus Metzeler; Christian Buske; Bob Löwenberg; Peter J M Valk; Peter W Zandstra; Mark D Minden; John E Dick; Jean C Y Wang
Journal:  Nature       Date:  2016-12-07       Impact factor: 49.962

Review 3.  The emerging complexity of gene fusions in cancer.

Authors:  Fredrik Mertens; Bertil Johansson; Thoas Fioretos; Felix Mitelman
Journal:  Nat Rev Cancer       Date:  2015-06       Impact factor: 60.716

4.  Super-enhancers in the control of cell identity and disease.

Authors:  Denes Hnisz; Brian J Abraham; Tong Ihn Lee; Ashley Lau; Violaine Saint-André; Alla A Sigova; Heather A Hoke; Richard A Young
Journal:  Cell       Date:  2013-10-10       Impact factor: 41.582

5.  Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.

Authors:  Loren M Lasko; Clarissa G Jakob; Rohinton P Edalji; Wei Qiu; Debra Montgomery; Enrico L Digiammarino; T Matt Hansen; Roberto M Risi; Robin Frey; Vlasios Manaves; Bailin Shaw; Mikkel Algire; Paul Hessler; Lloyd T Lam; Tamar Uziel; Emily Faivre; Debra Ferguson; Fritz G Buchanan; Ruth L Martin; Maricel Torrent; Gary G Chiang; Kannan Karukurichi; J William Langston; Brian T Weinert; Chunaram Choudhary; Peter de Vries; John H Van Drie; David McElligott; Ed Kesicki; Ronen Marmorstein; Chaohong Sun; Philip A Cole; Saul H Rosenberg; Michael R Michaelides; Albert Lai; Kenneth D Bromberg
Journal:  Nature       Date:  2017-09-27       Impact factor: 49.962

6.  The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability.

Authors:  Yun Huang; Brice Mouttet; Hans-Jörg Warnatz; Thomas Risch; Fabian Rietmann; Fabian Frommelt; Quy A Ngo; Maria Pamela Dobay; Blerim Marovca; Silvia Jenni; Yi-Chien Tsai; Sören Matzk; Vyacheslav Amstislavskiy; Martin Schrappe; Martin Stanulla; Matthias Gstaiger; Beat Bornhauser; Marie-Laure Yaspo; Jean-Pierre Bourquin
Journal:  Cancer Cell       Date:  2019-11-14       Impact factor: 31.743

7.  A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.

Authors:  Carsten Bahr; Lisa von Paleske; Veli V Uslu; Silvia Remeseiro; Naoya Takayama; Stanley W Ng; Alex Murison; Katja Langenfeld; Massimo Petretich; Roberta Scognamiglio; Petra Zeisberger; Amelie S Benk; Ido Amit; Peter W Zandstra; Mathieu Lupien; John E Dick; Andreas Trumpp; François Spitz
Journal:  Nature       Date:  2018-01-17       Impact factor: 49.962

8.  Conditional Expression of E2A-HLF Induces B-Cell Precursor Death and Myeloproliferative-Like Disease in Knock-In Mice.

Authors:  Jesús Duque-Afonso; Kevin S Smith; Michael L Cleary
Journal:  PLoS One       Date:  2015-11-20       Impact factor: 3.240

9.  Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.

Authors:  Ute Fischer; Michael Forster; Anna Rinaldi; Thomas Risch; Stéphanie Sungalee; Hans-Jörg Warnatz; Beat Bornhauser; Michael Gombert; Christina Kratsch; Adrian M Stütz; Marc Sultan; Joelle Tchinda; Catherine L Worth; Vyacheslav Amstislavskiy; Nandini Badarinarayan; André Baruchel; Thies Bartram; Giuseppe Basso; Cengiz Canpolat; Gunnar Cario; Hélène Cavé; Dardane Dakaj; Mauro Delorenzi; Maria Pamela Dobay; Cornelia Eckert; Eva Ellinghaus; Sabrina Eugster; Viktoras Frismantas; Sebastian Ginzel; Oskar A Haas; Olaf Heidenreich; Georg Hemmrich-Stanisak; Kebria Hezaveh; Jessica I Höll; Sabine Hornhardt; Peter Husemann; Priyadarshini Kachroo; Christian P Kratz; Geertruy Te Kronnie; Blerim Marovca; Felix Niggli; Alice C McHardy; Anthony V Moorman; Renate Panzer-Grümayer; Britt S Petersen; Benjamin Raeder; Meryem Ralser; Philip Rosenstiel; Daniel Schäfer; Martin Schrappe; Stefan Schreiber; Moritz Schütte; Björn Stade; Ralf Thiele; Nicolas von der Weid; Ajay Vora; Marketa Zaliova; Langhui Zhang; Thomas Zichner; Martin Zimmermann; Hans Lehrach; Arndt Borkhardt; Jean-Pierre Bourquin; Andre Franke; Jan O Korbel; Martin Stanulla; Marie-Laure Yaspo
Journal:  Nat Genet       Date:  2015-07-27       Impact factor: 38.330

10.  Critical Modulation of Hematopoietic Lineage Fate by Hepatic Leukemia Factor.

Authors:  Martin Wahlestedt; Vasileios Ladopoulos; Isabel Hidalgo; Manuel Sanchez Castillo; Rebecca Hannah; Petter Säwén; Haixia Wan; Monika Dudenhöffer-Pfeifer; Mattias Magnusson; Gudmundur L Norddahl; Berthold Göttgens; David Bryder
Journal:  Cell Rep       Date:  2017-11-21       Impact factor: 9.423
  10 in total
  1 in total

Review 1.  Resistance Mechanisms in Pediatric B-Cell Acute Lymphoblastic Leukemia.

Authors:  Krzysztof Jędraszek; Marta Malczewska; Karolina Parysek-Wójcik; Monika Lejman
Journal:  Int J Mol Sci       Date:  2022-03-12       Impact factor: 5.923
  1 in total

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